Asparagine synthetase: regulation by cell stress and involvement in tumor biology - Wikidata - awgldk - TriplyDB

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

http://www.wikidata.org/entity/Q34327474

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Enhanced oxidative stress resistance through activation of a zinc deficiency transcription factor in Brachypodium distachyon Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01 Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.Amino acid homeostasis and signalling in mammalian cells and organisms.Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae.Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.Heterogeneity research in muscle-invasive bladder cancer based on differential protein expression analysis.Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.Integrative analysis of the microRNA-mRNA response to radiochemotherapy in primary head and neck squamous cell carcinoma cells Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells.The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation.Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids.Metabolic control of tumour progression and antitumour immunity Translational regulator eIF2α in tumor.Targeting cancer cell metabolism in pancreatic adenocarcinoma.Targeting metabolic reprogramming in KRAS-driven cancers.Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.Targeting asparagine and autophagy for pulmonary adenocarcinoma therapy.Expression array analysis of the hepatocyte growth factor invasive program.Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established.Asparagine assimilation is critical for intracellular replication and dissemination of Francisella.Asparaginase pharmacology: challenges still to be faced.

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

http://www.wikidata.org/entity/Q34327474

description

2013 nî lūn-bûn

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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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AJPENDO.00015.2013

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American Journal of Physiology - Endocrinology and Metabolism

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Asparagine synthetase: regulation by cell stress and involvement in tumor biology

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P2093

Elizabeth A Butterworth

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Michael S Kilberg

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Mukundh N Balasubramanian

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P2860

Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability

Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin

Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase

C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product

Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.

Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells

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