Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
about
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.Targeting metabolic reprogramming in KRAS-driven cancers.Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.Glutamate and α-ketoglutarate: key players in glioma metabolism.Targeting amino acid metabolism for cancer therapy.A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.Revealing nascent proteomics in signaling pathways and cell differentiation.
P2860
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P2860
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
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2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
Functional genomic screening r ...... bolic vulnerability in sarcoma
@ast
Functional genomic screening r ...... bolic vulnerability in sarcoma
@en
type
label
Functional genomic screening r ...... bolic vulnerability in sarcoma
@ast
Functional genomic screening r ...... bolic vulnerability in sarcoma
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prefLabel
Functional genomic screening r ...... bolic vulnerability in sarcoma
@ast
Functional genomic screening r ...... bolic vulnerability in sarcoma
@en
P2093
P2860
P356
P1433
P1476
Functional genomic screening r ...... bolic vulnerability in sarcoma
@en
P2093
Amy J Wagers
Anna C Schinzel
Christina L Parker
Daria Tchessalova
Michaela Schneider
Nigel Gj Richards
Roderick T Bronson
Simone Hettmer
William C Hahn
P2860
P356
10.7554/ELIFE.09436
P407
P577
2015-10-24T00:00:00Z