Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
about
The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signalingGSK-3β: A Bifunctional Role in Cell Death PathwaysRegulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathwayPhosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapyThe transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progressionIMP dehydrogenase: structure, mechanism, and inhibition.miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulationFree fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolismCelecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumoursThe dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker valueThe cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motilityAkt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Discovering associations in biomedical datasets by link-based associative classifier (LAC)PKB/Akt partners with Dab2 in albumin endocytosisThe role of Akt/protein kinase B subtypes in retinal ischemic preconditioningInhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cellsFATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.Phosphoinositide-dependent pathways in mouse sperm are regulated by egg ZP3 and drive the acrosome reactionNeurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinomaIdentification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.Micropatterning of costimulatory ligands enhances CD4+ T cell function.Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Development of sulfonamide AKT PH domain inhibitors.PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression.Facilitating Akt clearance via manipulation of Hsp70 activity and levels.In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways.A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB.Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinaseThalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC).Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.The PIK3CA gene as a mutated target for cancer therapy.
P2860
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P2860
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@ast
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@en
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@nl
type
label
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@ast
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@en
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@nl
prefLabel
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@ast
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@en
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@nl
P2093
P1433
P1476
Akt/protein kinase B signaling ...... ncer cells overexpressing Akt.
@en
P2093
Andrew D Hamilton
Jin Q Cheng
Mark Polokoff
Qiyuan Liu
Richard I Feldman
Said M Sebti
Santo V Nicosia
P304
P356
10.1158/0008-5472.CAN-04-0343
P407
P577
2004-07-01T00:00:00Z