ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosisReview: The HSP90 molecular chaperone-an enigmatic ATPaseMaximizing the Therapeutic Potential of HSP90 InhibitorsTen things you should know about protein kinases: IUPHAR Review 14Functions of the Hsp90 chaperone system: lifting client proteins to new heightsStructural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1Raf-interactome in tuning the complexity and diversity of Raf function.The C-terminal domain of human Cdc37 studied by solution NMRAtomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinaseSelective targeting of the stress chaperome as a therapeutic strategyApplications of chemogenomic library screening in drug discoverySelective inhibition of the kinase DYRK1A by targeting its folding processStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Lapatinib for the treatment of breast cancer in the People's Republic of China.Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cellsPharmacological targeting of the pseudokinase Her3Applications of Biophysics in High-Throughput Screening Hit Validation.The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabineIdentification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells.Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cellsStructural and functional basis of protein phosphatase 5 substrate specificity.Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas.Discoidin domain receptors: a proteomic portrait.Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies.HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteinsUncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase AMutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes.How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37.Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma.Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance.Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
P2860
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P2860
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@ast
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@en
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@nl
type
label
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@ast
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@en
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@nl
prefLabel
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@ast
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@en
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@nl
P2860
P50
P356
P1476
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
@en
P2093
Sigrun Polier
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1212
P577
2013-03-17T00:00:00Z