MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
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OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic KinasesGenome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.MELK is not necessary for the proliferation of basal-like breast cancer cells.p53-independent p21 induction by MELK inhibition.CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.Identifying and analyzing different cancer subtypes using RNA-seq data of blood platelets.MELK expression correlates with tumor mitotic activity but is not required for cancer growth.Challenges in validating candidate therapeutic targets in cancer.
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P2860
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
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MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
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MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
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MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
@ast
MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
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MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
@ast
MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
@en
P2093
P2860
P356
P1433
P1476
MELK-T1, a small-molecule inhi ...... in proliferating cancer cells
@en
P2093
Aleyde Van Eynde
An De Bondt
Dirk Brehmer
Erika van Heerde
Ilse Van den Wyngaert
Joannes T M Linders
Lieven Meerpoel
P2860
P356
10.1042/BSR20150194
P50
P577
2015-10-02T00:00:00Z