Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
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GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitisCharacterization of 14-3-3-ζ Interactions with Integrin TailsNMR structure of integrin α4 cytosolic tail and its interactions with paxillinDistinct signaling mechanisms regulate migration in unconfined versus confined spacesNeurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrinsA small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation.Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growthReceptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus.Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growthIntegrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasisIntegrin antagonists as therapeutics for inflammatory diseases.Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs.Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationLocalized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migrationThe ins and outs of leukocyte integrin signaling.Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins.Role of beta7 integrins in intestinal lymphocyte homing and retention.RNAi-based therapeutic strategies for metabolic disease.Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.Paxillin is an intrinsic negative regulator of platelet activation in mice.Unique and redundant roles of alpha4 and beta2 integrins in kinetics of recruitment of lymphoid vs myeloid cell subsets to the inflamed peritoneum revealed by studies of genetically deficient mice.Myeloid cells in tumor inflammation.Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins.
P2860
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P2860
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@ast
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@en
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@nl
type
label
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@ast
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@en
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@nl
prefLabel
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@ast
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@en
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@nl
P2093
P2860
P356
P1476
Blocking the alpha 4 integrin- ...... itment to an inflammatory site
@en
P2093
Chloé C Féral
David M Rose
Gregg J Silverman
Jaewon Han
Kenneth Kaushansky
Mark H Ginsberg
P2860
P304
P356
10.1172/JCI26091
P407
P577
2006-02-09T00:00:00Z