Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis - Wikidata - awgldk - TriplyDB

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

http://www.wikidata.org/entity/Q34346934

about

Rac and Rho GTPases in cancer cell motility control The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage Therapeutic Implications of Targeting AKT Signaling in Melanoma Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo Regulation of ROCK activity in cancer Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth.Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model.RAS Interaction with PI3K: More Than Just Another Effector Pathway Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation Regulation of glioblastoma cell invasion by PKC iota and RhoB.Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells LFG-500 inhibits the invasion of cancer cells via down-regulation of PI3K/AKT/NF-κB signaling pathway AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.Activation of the RhoB signaling pathway by thyroid hormone receptor β in thyroid cancer cells Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.Critical functions of RhoB in support of glioblastoma tumorigenesis The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors.RhoB upregulation leads to either apoptosis or cytostasis through differential target selection.RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma.Oncogenic Ras in tumour progression and metastasis.RhoB mediates antitumor synergy of combined ixabepilone and sunitinib in human ovarian serous cancer.Rho proteins and cell-matrix interactions in cancer.RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27.Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.Emerging molecular targets in melanoma invasion and metastasis.Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells

P2860

Q21245504-18CB6CFE-FD28-4897-83A8-070B0796BEE1 Q24294754-029B75D9-68F3-49E9-8CD6-1D52664083AF Q24631438-EE1F6381-27A1-4D45-B94D-FE3A1D007B98 Q24651313-F350634C-32B2-4FDA-A5F4-4F548DD6239D Q24680658-CE99979D-9385-46B0-B6EF-068D2F916295 Q24685451-F27D286C-3FA5-446F-B004-89FD9C98FF1D Q27006554-C857A0AC-4EBB-4F52-AC91-08C4C7FDF1E5 Q28476172-B195B1D5-14B4-4655-AC9C-D40D0CA35D9D Q28727877-1E956EC3-BAE3-4441-A39C-3488F469B182 Q30438923-5F67AC18-ED9D-4E8E-8FC0-DFD54B1C476A Q33588169-1955B59D-6282-4F3C-B460-A3B1D3856E7E Q33645244-5C93AFF4-ED16-4C40-99C5-3B964CEDFF18 Q33648384-0634F63D-6909-473E-8C25-BA2AD0CA9F93 Q34000333-E2C9C5C5-8AD6-4D70-B95A-22F72E004FF1 Q34202692-6B3D041D-F913-4A8E-A830-1222DBC71771 Q34418045-47EE52DF-19DC-4E2B-9CB1-CD20D8CC20F9 Q34449752-C0A48FC2-24A5-45C2-8D04-7E7CB4207DE9 Q34739540-E75A386D-778F-4E57-BCB8-F22059F6368A Q35095146-B520BC16-D107-400B-9042-5A181178FE5C Q35117685-069048C9-51C1-42CE-ACBD-EAD1C9C7A911 Q35190395-FE846A43-F8C8-4A85-B2C6-3A48008B06FF Q35535645-FE7EAE1F-3486-45BF-A5E7-11F5D3CE4A59 Q35604206-B0A958C0-7779-4276-B674-4E0BE8FA9212 Q35788796-30E8A667-7CA8-422E-9AE1-B6D42254ADD5 Q36020990-DAB17B30-1944-442D-9722-E9D4B24C174C Q36027160-E7F66397-1A9E-4A44-901D-C7DDCA77D373 Q36069147-BBBC4D77-9924-4661-879A-59119A26BCD3 Q36103287-A9DCBEC3-0FD7-48BD-BD4A-A994BE164F78 Q36308299-70AF6A5C-C6C4-4ECD-B472-B10FB1F64221 Q36857792-20E6B000-217D-4A9A-A327-EE79242BD4D4 Q37219345-EC6BBACC-F6B6-4131-82B9-703E6ECA84B3 Q37302262-C5321835-80B0-4437-8D96-ED1167360AAE Q37344074-C139C594-B687-4A75-9FDA-CCF1E78B73DC Q37398646-E5DE5233-99D7-429C-800E-43E948528220 Q37506648-C4C5CFB2-FF4E-4AC9-8804-9CE2B46BF256 Q38055272-31FF2A8C-915C-4A52-B930-D88EA21B4036 Q38330587-BAF21330-3B85-4AB4-933E-5732637B2BC8 Q38334527-C91DB137-127A-4EBF-A161-7B1ABA4E05D4 Q38515287-B13C416A-4D18-4C0E-8DF9-687A7FA3DA57 Q38865384-48AB7D2C-CDD0-46CB-A2C8-136F9878E575

P2860

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

http://www.wikidata.org/entity/Q34346934

description

2004 nî lūn-bûn

@nan

2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@ast

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@en

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@nl

type

label

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@ast

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@en

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@nl

prefLabel

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@ast

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@en

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@nl

P1433

Q34346934-E0469F53-D23F-4D65-9DF6-70630D1318F6

P1476

Q34346934-87994C40-65B7-41B8-BA4B-535F9CBD03D1

P2093

Q34346934-2F26BCB5-8710-43ED-857F-412B620F29E7

Q34346934-3461B503-E619-4FC6-ABA3-5A4A8E65B691

Q34346934-5B3F627B-7EB8-476A-8DB8-0E54D70CBDC2

Q34346934-8C1F654F-941C-4BCD-8A87-14F74958492D

Q34346934-92A46A11-6CA5-4B0F-A91B-A7C7B693EFA4

Q34346934-D4A28C9C-2ECD-4665-A601-7F07F836BE20

P2860

Q34346934-03D269FF-A6D0-4797-8B73-2F0FD2EAA374

Q34346934-0B86D5EF-F61A-40B3-A37B-2E893298DD3F

Q34346934-0F2EDB8E-4B93-4682-88B3-A855C635BEB6

Q34346934-13481EB0-2133-4D16-A538-AED56BDCB80F

Q34346934-1A1DC401-C0E7-4C02-AD0F-70C296BE7D4E

Q34346934-2170F4A9-7D73-4358-B6E7-FE1D021AC151

Q34346934-228E4872-6C74-4BF5-92FA-50728F4DECFD

Q34346934-236E1F19-431A-4C58-9F10-4D547A8A3664

Q34346934-24533EED-B747-427C-8A94-912D828F6D1F

Q34346934-2A214814-9A8B-4308-BE04-13A4D0D15CE1

P304

Q34346934-6A0A4902-1D09-4410-9AD4-2A7F93308CEA

P31

Q34346934-185D8C8D-9CEF-422D-A3A0-A5559B3CDFD2

P356

Q34346934-6CF9F8EF-989F-42E2-86DF-41D4326DD872

P407

Q34346934-0B85784E-F058-41AA-9EF2-864576698A4D

P433

Q34346934-71CB57C0-9D66-465A-ADD8-34EA4AEB4D8B

P478

Q34346934-12B04E46-F78B-4D16-87E7-4F5DD1B4631A

P577

Q34346934-D761F1B1-A9FA-4250-A563-1E725D927B9D

P698

Q34346934-25F25E32-EDCF-4A0B-8285-DB72089DFD50

P932

Q34346934-1D8CE6DA-FB9D-4896-8F2A-A0A43992BD0D

P356

MCB.24.12.5565-5576.2004

P1433

Molecular and Cellular Biology

P1476

Akt mediates Ras downregulatio ...... tion, invasion, and metastasis

@en

P2093

Jiazhi Sun

http://www.w3.org/2001/XMLSchema#string

Jin Cheng

http://www.w3.org/2001/XMLSchema#string

Julie Y Djeu

http://www.w3.org/2001/XMLSchema#string

Kun Jiang

http://www.w3.org/2001/XMLSchema#string

Saïd Sebti

http://www.w3.org/2001/XMLSchema#string

Sheng Wei

http://www.w3.org/2001/XMLSchema#string

P2860

CDC42 and FGD1 cause distinct signaling and transforming activities.

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

Ras-related GTPase Rhob represses NF-kappaB signaling.

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

Rho GTPases: signaling, migration, and invasion.

P304

5565-5576

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.24.12.5565-5576.2004

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P577

2004-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15169915

http://www.w3.org/2001/XMLSchema#string

P932

419878

http://www.w3.org/2001/XMLSchema#string