Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
about
Differential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinibCytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effectDetection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitisChanges in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesisStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Summary of information on human CYP enzymes: human P450 metabolism data.[Metabolism of xenobiotics: beneficial and adverse effects].Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors.DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.Development of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivatorIdentification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Role of metabolism in drug-induced idiosyncratic hepatotoxicity.Numerical analysis of time dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting.Theragenomic knowledge management for individualised safety of drugs, chemicals, pollutants and dietary ingredients.Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.Idiosyncratic reactions and metabolism of sulfur-containing drugs.Drug-mediated inactivation of cytochrome P450.Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites.Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection.Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
P2860
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P2860
Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@ast
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@en
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@nl
type
label
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@ast
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@en
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@nl
prefLabel
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@ast
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@en
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@nl
P2093
P356
P1433
P1476
Thiophene derivatives as new m ...... me P-450 2C9 by tienilic acid.
@en
P2093
Dansette PM
López-Garcia MP
P304
P356
10.1021/BI00167A022
P407
P577
1994-01-01T00:00:00Z