Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.
about
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturationMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifHIV-1 IN/Pol recruits LEDGF/p75 into viral particlesMethods for the creation of cyclic Peptide libraries for use in lead discovery.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.MLL leukemia and future treatment strategies.Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides.TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.Different Pathways Leading to Integrase Inhibitors ResistanceSmall-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.Inhibiting the HIV integration process: past, present, and the future.LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor.Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl-prolyl isomerase Pin1.Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.
P2860
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P2860
Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Phage display-directed discove ...... inhibitors of HIV replication.
@ast
Phage display-directed discove ...... inhibitors of HIV replication.
@en
Phage display-directed discove ...... inhibitors of HIV replication.
@nl
type
label
Phage display-directed discove ...... inhibitors of HIV replication.
@ast
Phage display-directed discove ...... inhibitors of HIV replication.
@en
Phage display-directed discove ...... inhibitors of HIV replication.
@nl
prefLabel
Phage display-directed discove ...... inhibitors of HIV replication.
@ast
Phage display-directed discove ...... inhibitors of HIV replication.
@en
Phage display-directed discove ...... inhibitors of HIV replication.
@nl
P2093
P2860
P50
P356
P1433
P1476
Phage display-directed discove ...... inhibitors of HIV replication
@en
P2093
Belete A Desimmie
Frauke Christ
Michael Humbert
Rik Gijsbers
Ruth M Ruprecht
Sofie Vets
P2860
P304
P356
10.1038/MT.2012.132
P577
2012-07-24T00:00:00Z