LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes - Wikidata - awgldk - TriplyDB

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

http://www.wikidata.org/entity/Q24562936

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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus Virological and cellular roles of the transcriptional coactivator LEDGF/p75 Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity Mouse mammary tumor virus integration site selection in human and mouse genomes LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration Retroviruses 2004: review of the 2004 Cold Spring Harbor Retroviruses Conference Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import The cell cycle independence of HIV infections is not determined by known karyophilic viral elements.A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo Expression of hepatoma-derived growth factor family members in the adult central nervous system.Cellular and viral determinants of retroviral nuclear entry Retroviral integrations in gene therapy trials Human immunodeficiency virus (HIV)-1 integration sites in viral latency Structural basis for functional tetramerization of lentiviral integrase p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes Allosteric Inhibition of Human Immunodeficiency Virus Integrase A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75 Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment Strand transfer and elongation of HIV-1 reverse transcription is facilitated by cell factors in vitro LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain Retroviral DNA Integration LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity DNA double strand break repair enzymes function at multiple steps in retroviral infection.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Inhibition of early steps of HIV-1 replication by SNF5/Ini1.Retroviral DNA integration: viral and cellular determinants of target-site selection High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

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P2860

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

http://www.wikidata.org/entity/Q24562936

description

2004 nî lūn-bûn

@nan

2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

LEDGF/p75 determines cellular ...... viral preintegration complexes

@ast

LEDGF/p75 determines cellular ...... viral preintegration complexes

@en

LEDGF/p75 determines cellular ...... viral preintegration complexes

@nl

type

label

LEDGF/p75 determines cellular ...... viral preintegration complexes

@ast

LEDGF/p75 determines cellular ...... viral preintegration complexes

@en

LEDGF/p75 determines cellular ...... viral preintegration complexes

@nl

prefLabel

LEDGF/p75 determines cellular ...... viral preintegration complexes

@ast

LEDGF/p75 determines cellular ...... viral preintegration complexes

@en

LEDGF/p75 determines cellular ...... viral preintegration complexes

@nl

P1433

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P356

JVI.78.17.9524-9537.2004

P1433

Journal of Virology

P1476

LEDGF/p75 determines cellular ...... viral preintegration complexes

@en

P2093

Dyana Saenz

http://www.w3.org/2001/XMLSchema#string

Eric M Poeschla

http://www.w3.org/2001/XMLSchema#string

Manuel Llano

http://www.w3.org/2001/XMLSchema#string

Maria Vanegas

http://www.w3.org/2001/XMLSchema#string

Mary Peretz

http://www.w3.org/2001/XMLSchema#string

Oliver Fregoso

http://www.w3.org/2001/XMLSchema#string

Susan Chung

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

A previously unidentified host protein protects retroviral DNA from autointegration

A novel receptor-mediated nuclear protein import pathway

Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex

The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes

P304

9524-37

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scholarly article

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2673674

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10.1128/JVI.78.17.9524-9537.2004

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17

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78

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2004-09-01T00:00:00Z

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15308744

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P932

506940

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