Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.
about
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7A single sodium channel mutation produces hyper- or hypoexcitability in different types of neuronsPain as a channelopathyA Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivityGenetic neurological channelopathies: molecular genetics and clinical phenotypes.Primary erythromelalgia: a reviewNav1.7 and other voltage-gated sodium channels as drug targets for pain reliefNeurobiology: a channel sets the gain on painSubtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical propertiesVoltage-gated Na+ channels in neuropathic pain.A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Excitability constraints on voltage-gated sodium channelsUpregulation of nav1.7 through high salt loading: (mol pain 2013;9:39)Burning pain: axonal dysfunction in erythromelalgia.Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathyAlternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T.Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disordersInherited disorders of voltage-gated sodium channels.Challenges in the development of novel treatment strategies for neuropathic pain.Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutationsSize matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.A novel SCN9A mutation responsible for primary erythromelalgia and is resistant to the treatment of sodium channel blockersMutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.The roles of sodium channels in nociception: Implications for mechanisms of painLinkage between increased nociception and olfaction via a SCN9A haplotypeNav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.Recombinant expression and in vitro characterisation of active Huwentoxin-IV.Familial neuralgia of occipital and intermedius nerves in a Chinese family.Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.Navβ4 regulates fast resurgent sodium currents and excitability in sensory neuronsThe Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia.Sodium channel mutations in epilepsy and other neurological disorders.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromesNetwork topology of NaV1.7 mutations in sodium channel-related painful disorders.Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade
P2860
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P2860
Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Electrophysiological propertie ...... painful inherited neuropathy.
@ast
Electrophysiological propertie ...... painful inherited neuropathy.
@en
Electrophysiological propertie ...... painful inherited neuropathy.
@nl
type
label
Electrophysiological propertie ...... painful inherited neuropathy.
@ast
Electrophysiological propertie ...... painful inherited neuropathy.
@en
Electrophysiological propertie ...... painful inherited neuropathy.
@nl
prefLabel
Electrophysiological propertie ...... painful inherited neuropathy.
@ast
Electrophysiological propertie ...... painful inherited neuropathy.
@en
Electrophysiological propertie ...... painful inherited neuropathy.
@nl
P2093
P1476
Electrophysiological propertie ...... a painful inherited neuropathy
@en
P2093
Stephen G Waxman
Sulayman D Dib-Hajj
Theodore R Cummins
P304
P356
10.1523/JNEUROSCI.2695-04.2004
P407
P577
2004-09-01T00:00:00Z