Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
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Monastrol inhibition of the mitotic kinesin Eg5.Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanismsAllosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding siteAnalysis of the interaction of the Eg5 Loop5 with the nucleotide siteATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrolGrowing the growth cone: remodeling the cytoskeleton to promote axon regenerationAn allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complexOptimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft ModelsTriphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor ActivitySmall-molecule and mutational analysis of allosteric Eg5 inhibition by monastrolEssential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Kinesin-5 inhibitor resistance is driven by kinesin-12Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesKinesin-5 motors are required for organization of spindle microtubules in Silvetia compressa zygotes.A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approachLocalization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa.KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysisLamins position the nuclear pores and centrosomes by modulating dynein.Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present).Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes.Crystal structure of ethyl 6-(2-fluoro-phen-yl)-4-hy-droxy-2-sulfanyl-idene-4-tri-fluoro-meth-yl-1,3-diazinane-5-carboxyl-ate.S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.rac-Ethyl 4-hy-droxy-6-(2-hy-droxy-phen-yl)-2-oxo-4-(trifluoro-methyl)per-hydro-pyrimidine-5-carboxyl-aterac-6-Hy-droxy-4-(4-nitro-phen-yl)-5-(2-thienyl-carbon-yl)-6-(trifluoro-meth-yl)-3,4,5,6-tetra-hydro-pyrimidin-2(1H)-one monohydrate5-Benzoyl-4-hydr-oxy-6-(4-nitro-phen-yl)-4-trifluoro-meth-yl-3,4,5,6-tetrahydro-pyrimidin-2(1H)-one monohydrate.rac-Ethyl 4-hy-droxy-4-trifluoro-methyl-6-(2,4,5-trimeth-oxy-phen-yl)-2-thio-1,3-diazinane-5-carboxyl-ate.Ethyl 6-(4-fluoro-phen-yl)-4-hy-droxy-2-oxo-4-trifluoro-meth-yl-1,3-diazinane-5-carboxyl-ate monohydrate.Ethyl 6-(4-fluoro-phen-yl)-4-hy-droxy-2-sulfanyl-idene-4-trifluoro-methyl-1,3-diazinane-5-carboxyl-ate.Ethyl 6-[4-(dimethyl-amino)phen-yl]-4-hydr-oxy-2-oxo-4-(trifluoro-methyl)-hexa-hydro-pyrimidine-5-carboxyl-ate.Ethyl 4-hy-droxy-6-(4-hy-droxy-phen-yl)-4-trifluoro-methyl-2-sulfanyl-idene-1,3-diazinane-5-carboxyl-ate ethanol monosolvate.Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions.Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope.
P2860
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P2860
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Identification of the protein ...... or of the mitotic kinesin Eg5.
@ast
Identification of the protein ...... or of the mitotic kinesin Eg5.
@en
Identification of the protein ...... or of the mitotic kinesin Eg5.
@nl
type
label
Identification of the protein ...... or of the mitotic kinesin Eg5.
@ast
Identification of the protein ...... or of the mitotic kinesin Eg5.
@en
Identification of the protein ...... or of the mitotic kinesin Eg5.
@nl
prefLabel
Identification of the protein ...... or of the mitotic kinesin Eg5.
@ast
Identification of the protein ...... or of the mitotic kinesin Eg5.
@en
Identification of the protein ...... or of the mitotic kinesin Eg5.
@nl
P2093
P356
P1433
P1476
Identification of the protein ...... or of the mitotic kinesin Eg5.
@en
P2093
David Lemaire
Eric Forest
Frank Kozielski
Salvatore Debonis
Sébastien Brier
P304
13072-13082
P356
10.1021/BI049264E
P407
P577
2004-10-01T00:00:00Z