High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio - Wikidata - awgldk - TriplyDB

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

http://www.wikidata.org/entity/Q34359196

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Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle Reprogramming of energy metabolism as a driver of aging Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Formaldehyde in brain: an overlooked player in neurodegeneration?Is L-lactate a novel signaling molecule in the brain?Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain Nuclear DNA damage signalling to mitochondria in ageing Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation Regulation of pyruvate metabolism and human disease Glycolytic reliance promotes anabolism in photoreceptors.Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution.Neuroglobin mitigates mitochondrial impairments induced by acute inhalation of combustion smoke in the mouse brain.Maternally transmitted mitochondrial DNA mutations can reduce lifespan Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's.Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.Six fucose-α(1-2) sugars and α-fucose assigned in the human brain using in vivo two-dimensional MRS.Age-related changes in the central auditory system.Age-related metabolic fatigue during low glucose conditions in rat hippocampus.Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry.Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice.Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis.Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites.Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness.Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies.Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.Excitatory action of GABA on immature neurons is not due to absence of ketone bodies metabolites or other energy substrates.The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.Cerebellar Molecular and Cellular Characterization in Rat Models of Alzheimer's Disease: Neuroprotective Mechanisms of Garcinia Biflavonoid Complex.Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease.Differential expression of genes related to glucose metabolism in domesticated pigs and wild boar.

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P2860

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

http://www.wikidata.org/entity/Q34359196

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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PNAS.1008189107

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Proceedings of the National Academy of Sciences of the United States of America

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High brain lactate is a hallma ...... actate dehydrogenase A/B ratio

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Aleksandra Trifunovic

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Barry J Hoffer

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Giuseppe Coppotelli

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Jaime M Ross

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Jan Kehr

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Johanna Öberg

http://www.w3.org/2001/XMLSchema#string

Karin Pernold

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Lars Olson

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Michel Goiny

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Mügen Terzioglu

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P2860

Lactate fuels the human brain during exercise

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

The biologic clock: the mitochondria?

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders.

Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T.

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.

Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles

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20087-20092

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scholarly article

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10.1073/PNAS.1008189107

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46

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107

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Nils-Göran Larsson

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2010-11-01T00:00:00Z

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47644912

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21041631

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2993405

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