Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons
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Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal.Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance.Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum.Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental areaβ-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.Repeated morphine treatment alters cannabinoid modulation of GABAergic synaptic transmission within the rat periaqueductal grey.A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance.Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neuronsMorphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse.D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats.Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat.The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.Pain: novel analgesics from traditional Chinese medicines.Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray.Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance.Desensitization and tolerance of mu opioid receptors on pontine Kolliker-Fuse neurons.Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence.Emerging Evidence for Cannabis' Role in Opioid Use Disorder
P2860
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P2860
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@ast
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@en
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@nl
type
label
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@ast
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@en
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@nl
prefLabel
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@ast
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@en
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@nl
P2093
P2860
P356
P1476
Tolerance to the antinocicepti ...... at periaqueductal gray neurons
@en
P2093
Daniel R Cleary
Leon W Fyfe
Michael M Morgan
Susan L Ingram
Tara A Macey
P2860
P304
P356
10.1124/JPET.110.172643
P407
P577
2010-08-25T00:00:00Z