Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
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Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signalingEndothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- miceHerkinorin analogues with differential beta-arrestin-2 interactionsbeta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceEssential role for RGS9 in opiate actionImprovement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matterEngineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingStructure-based discovery of opioid analgesics with reduced side effects.Targeting G protein coupled receptor-related pathways as emerging molecular therapiesμ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacologyOpioid receptor heteromers in analgesiaPositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsIn vivo delta opioid receptor internalization controls behavioral effects of agonistsCurrent research on opioid receptor function.Gα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years laterLigand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-targetAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismMultiple actions of spinophilin regulate mu opioid receptor functionActivation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talkMembrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recyclingADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosisReceptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimersTargeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in miceArrestin-Bound Rhodopsin: A Molecular Structure and its Impact on the Development of Biased GPCR Ligands.Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers.Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the EndorphinsCritical role of toll-like receptor 9 in morphine and Mycobacterium tuberculosis-Induced apoptosis in mice.Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacyβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.Toll-like receptor 9 is required for opioid-induced microglia apoptosis.Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.How to design an opioid drug that causes reduced tolerance and dependence.Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system.The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
P2860
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P2860
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
description
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2000
@ast
scientific journal article
@en
vedecký článok (publikovaný 2000/12/07)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/12/07)
@nl
наукова стаття, опублікована в грудні 2000
@uk
مقالة علمية (نشرت في 7-12-2000)
@ar
name
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@ast
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@en
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@nl
type
label
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@ast
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@en
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@nl
prefLabel
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@ast
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@en
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@nl
P2093
P3181
P356
P1433
P1476
Mu-opioid receptor desensitiza ...... e tolerance but not dependence
@en
P2093
L. M. Bohn
M. G. Caron
R. J. Lefkowitz
R. R. Gainetdinov
P2888
P304
P3181
P356
10.1038/35047086
P407
P577
2000-12-07T00:00:00Z
P5875
P6179
1004603593