Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. - Wikidata - awgldk - TriplyDB

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.

http://www.wikidata.org/entity/Q34372000

about

Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases Regulatory Roles of MAPK Phosphatases in Cancer BRAF Mutation in Hairy Cell Leukemia TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways miR-24 regulates menin in the endocrine pancreas Two novel RUNX1 mutations in a patient with congenital thrombocytopenia that evolved into a high grade myelodysplastic syndrome Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs.Preferential star strand biogenesis of pre-miR-24-2 targets PKC-alpha and suppresses cell survival in MCF-7 breast cancer cells Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Mitogen activated protein kinase phosphatases and cancer.Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer.Metastatic bone disease: role of transcription factors and future targets.A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program.Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases MiR-24 promotes the survival of hematopoietic cells RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Increased expression of miR-24 is associated with acute myeloid leukemia with t(8;21).High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia.Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway.DUSPs, to MAP kinases and beyond.Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1.Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity.MicroRNA control of bone formation and homeostasis.MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells.MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunction The Role of miRNA in Haematological Malignancy.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.An architectural genetic and epigenetic perspective.MicroRNAs in the midst of myeloid signal transduction.MicroRNAs in acute leukemia: from biological players to clinical contributors.MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia.AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.RUNX1: A microRNA hub in normal and malignant hematopoiesis.Targeting deregulated epigenetic control in cancer.Non-coding RNAs: Epigenetic regulators of bone development and homeostasis.Therapeutic Targeting of microRNAs in Cancer: Future Perspectives.

P2860

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P2860

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.

http://www.wikidata.org/entity/Q34372000

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@ast

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@en

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@nl

type

label

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@ast

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@en

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@nl

prefLabel

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@ast

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@en

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@nl

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0008-5472.CAN-09-1567

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Cancer Research

P1476

Altered Runx1 subnuclear targe ...... g a miR-24/MKP-7/MAPK network.

@en

P2093

Andre J van Wijnen

http://www.w3.org/2001/XMLSchema#string

Azra Raza

http://www.w3.org/2001/XMLSchema#string

Christopher R Dowdy

http://www.w3.org/2001/XMLSchema#string

Gary S Stein

http://www.w3.org/2001/XMLSchema#string

Jane B Lian

http://www.w3.org/2001/XMLSchema#string

Janet L Stein

http://www.w3.org/2001/XMLSchema#string

Sayyed K Zaidi

http://www.w3.org/2001/XMLSchema#string

P2860

MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

The functions of animal microRNAs

MicroRNAs modulate hematopoietic lineage differentiation

MicroRNAs: small RNAs with a big role in gene regulation

MicroRNAs: genomics, biogenesis, mechanism, and function

AML1 interconnected pathways of leukemogenesis

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

RUNX1/AML1: a central player in hematopoiesis

microRNAs: tiny regulators with great potential

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scholarly article

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10.1158/0008-5472.CAN-09-1567

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P433

21

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69

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Carlo Maria Croce

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2009-10-13T00:00:00Z

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26891655

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19826043

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2995702

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