Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
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The hedgehog pathway in triple-negative breast cancerNon-Canonical Hh Signaling in Cancer-Current Understanding and Future DirectionsCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyContemporary murine models in preclinical astrocytoma drug developmentGlioblastoma Stem-Like Cells: Characteristics, Microenvironment, and TherapyHedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clustersA phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057KActivation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathwaySmoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell linesRecent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical developmentSonic hedgehog signaling in the postnatal brain.The mTOR signaling pathway as a treatment target for intracranial neoplasmsRepurposing the antihelmintic mebendazole as a hedgehog inhibitor.Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBMPI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cellsTargeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical updateHedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retinaDesert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma.PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotypeRationale-based therapeutic combinations with PI3K inhibitors in cancer treatmentCombination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response.Hedgehog: Multiple Paths for Multiple Roles in Shaping the Brain and Spinal Cord.Molecular and genetic pathways in gliomas: the future of personalized therapeutics.Mechanisms regulating glioma invasion.EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT).Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcomaPreclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.p70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation.The Crossroads of Neural Stem Cell Development and Tumorigenesis.Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Sonic Hedgehog Signaling in Thyroid Cancer.mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells.A synthetic combinatorial approach to disabling deviant Hedgehog signaling.
P2860
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P2860
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Coordinate activation of Shh a ...... new therapeutic opportunities.
@ast
Coordinate activation of Shh a ...... new therapeutic opportunities.
@en
Coordinate activation of Shh a ...... new therapeutic opportunities.
@nl
type
label
Coordinate activation of Shh a ...... new therapeutic opportunities.
@ast
Coordinate activation of Shh a ...... new therapeutic opportunities.
@en
Coordinate activation of Shh a ...... new therapeutic opportunities.
@nl
prefLabel
Coordinate activation of Shh a ...... new therapeutic opportunities.
@ast
Coordinate activation of Shh a ...... new therapeutic opportunities.
@en
Coordinate activation of Shh a ...... new therapeutic opportunities.
@nl
P2093
P2860
P356
P1433
P1476
Coordinate activation of Shh a ...... new therapeutic opportunities.
@en
P2093
Barbara Tabak
David S Shulman
Ekaterina Pak
Jarom Chung
Joseph F Kelleher
Keith L Ligon
Maria F Pazyra-Murphy
Mariella Gruber Filbin
Marion Dorsch
P2860
P2888
P304
P356
10.1038/NM.3328
P407
P577
2013-09-29T00:00:00Z