A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.
about
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneIdentification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin geneFunctional analysis of the nuclear LIM domain interactor NLITranscriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificityIsolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expressionGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationPax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancerRole of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphomaPancreatic beta cells require NeuroD to achieve and maintain functional maturityCovalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells.Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I geneMultiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells.A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancerTissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivoBeta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter.Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expressionThe NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein bindingA cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene.The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region.Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells.Pancreatic beta cells express a diverse set of homeobox genes.Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38)Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediatesGlucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured isletsThe E2A gene product contains two separable and functionally distinct transcription activation domains.c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene productsCharacterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line.BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes.Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.
P2860
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P2860
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.
description
1987 nî lūn-bûn
@nan
1987 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
A mutational analysis of the i ...... sequences within the enhancer.
@ast
A mutational analysis of the i ...... sequences within the enhancer.
@en
A mutational analysis of the i ...... sequences within the enhancer.
@nl
type
label
A mutational analysis of the i ...... sequences within the enhancer.
@ast
A mutational analysis of the i ...... sequences within the enhancer.
@en
A mutational analysis of the i ...... sequences within the enhancer.
@nl
prefLabel
A mutational analysis of the i ...... sequences within the enhancer.
@ast
A mutational analysis of the i ...... sequences within the enhancer.
@en
A mutational analysis of the i ...... sequences within the enhancer.
@nl
P2093
P2860
P356
P1476
A mutational analysis of the i ...... sequences within the enhancer.
@en
P2093
P2860
P304
P356
10.1073/PNAS.84.24.8819
P407
P577
1987-12-01T00:00:00Z