Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants - Wikidata - awgldk - TriplyDB

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

http://www.wikidata.org/entity/Q34377776

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Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Decoding the non-coding genome: elucidating genetic risk outside the coding genome Epigenetic Codes Programing Class Switch Recombination Transcriptional enhancers: functional insights and role in human disease The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics Exploiting genomics and natural genetic variation to decode macrophage enhancers SMC complexes link gene expression and genome architecture Super-enhancers: Asset management in immune cell genomes Investigating the transcriptional control of cardiovascular development Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers The selection and function of cell type-specific enhancers The mechanisms behind the therapeutic activity of BET bromodomain inhibition Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs dbSUPER: a database of super-enhancers in mouse and human genome BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach Genetic and epigenetic fine mapping of causal autoimmune disease variants Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency The genetic architecture of type 2 diabetes Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.Joint analysis of functional genomic data and genome-wide association studies of 18 human traits.Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.The Pancreatic Islet Regulome Browser.Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.Platelet function is modified by common sequence variation in megakaryocyte super enhancers Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.Enhancers as non-coding RNA transcription units: recent insights and future perspectives.Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.Enhancing the understanding of asthma.NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes.Super-enhancers delineate disease-associated regulatory nodes in T cells.Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.Transcription factor co-occupied regions in the murine genome constitute T-helper-cell subtype-specific enhancers.The pancreatic β cell: recent insights from human genetics.

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

http://www.wikidata.org/entity/Q34377776

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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Chromatin stretch enhancer sta ...... or human disease risk variants

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PNAS.1317023110

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Proceedings of the National Academy of Sciences of the United States of America

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Chromatin stretch enhancer sta ...... or human disease risk variants

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D Leland Taylor

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Jennifer A Akiyama

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Jose Miguel Orozco

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Kelly Lammerts van Bueren

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Len A Pennacchio

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Michael L Stitzel

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Michael R Erdos

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NISC Comparative Sequencing Program Authors

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National Institutes of Health ...... ive Sequencing Program Authors

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Peter S Chines

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A user's guide to the encyclopedia of DNA elements (ENCODE)

An integrated encyclopedia of DNA elements in the human genome

Five years of GWAS discovery

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Locus control regions

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

Mapping and analysis of chromatin state dynamics in nine human cell types

Discovery and characterization of chromatin states for systematic annotation of the human genome

Systematic localization of common disease-associated variation in regulatory DNA

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17921-17926

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44

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110

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Francis Collins

NISC Comparative Sequencing Program

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2013-10-14T00:00:00Z

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257815258

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24127591

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3816444

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