The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
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Lysophospholipids and their receptors in the central nervous systemSphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in ratsSphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesiaIntraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo.Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons.Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.Sphingosine lysolipids in the CNS: endogenous cannabinoid antagonists or a parallel pain modulatory system?Activation of S1P₁ receptor regulates PI3K/Akt/FoxO3a pathway in response to oxidative stress in PC12 cells.Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion.Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.
P2860
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P2860
The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
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2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@ast
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@en
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@nl
type
label
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@ast
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@en
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@nl
prefLabel
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@ast
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@en
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@nl
P2860
P356
P1476
The sphingosine 1-phosphate re ...... citability of sensory neurons.
@en
P2093
Xian Xuan Chi
P2860
P304
P356
10.1152/JN.00709.2010
P407
P577
2010-09-15T00:00:00Z