The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.
about
Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainp63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.Function and regulation of the Rho guanine nucleotide exchange factor TrioInvolvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophyPAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiologySignaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular locationSomatostatin inhibits cell migration and reduces cell counts of human keratinocytes and delays epidermal wound healing in an ex vivo wound modelStrike a pose: Gαq complexes at the membranep63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein GαqProtease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cellsStructure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cellsReal-time visualization of heterotrimeric G protein Gq activation in living cellsRole of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayersEvolution of a signaling nexus constrained by protein interfaces and conformational States.Regulation of GPCR signaling in hypertension.Constitutive β-catenin signaling by the viral chemokine receptor US28Muscarinic receptor signaling in the pathophysiology of asthma and COPD.Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida.UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway.WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signalingGastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegansPlasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells.Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodesProtein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasisSimilarities and differences in the autonomic control of airway and urinary bladder smooth muscleA functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.Emerging role of G protein-coupled receptors in microvascular myogenic tone.
P2860
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P2860
The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@ast
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@en
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@nl
type
label
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@ast
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@en
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@nl
prefLabel
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@ast
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@en
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@nl
P2093
P356
P1476
The guanine nucleotide exchang ...... d receptor signaling and RhoA.
@en
P2093
Andrea Freichel-Blomquist
Karl H Jakobs
Martina Schmidt
Susanne Lutz
Thomas Wieland
Ulrich Rümenapp
P304
11134-11139
P356
10.1074/JBC.M411322200
P407
P577
2005-01-04T00:00:00Z