Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. - Wikidata - awgldk - TriplyDB

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

http://www.wikidata.org/entity/Q34387585

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Comparative study of methyl-CpG-binding domain proteins Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice Medicine. Activating a repressor MeCP2, a key contributor to neurological disease, activates and represses transcription Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes The odyssey of MeCP2 and parental imprinting Rett syndrome: clinical review and genetic update DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease Epigenetics and psychostimulant addiction The impact of MeCP2 loss- or gain-of-function on synaptic plasticity BDNF deregulation in Rett syndrome Epigenetics and drug addiction: a focus on MeCP2 and on histone acetylation Role of mecp2 in experience-dependent epigenetic programming Rett syndrome - biological pathways leading from MECP2 to disorder phenotypes MeCP2: the chromatin connection and beyond Components of the DNA methylation system of chromatin control are RNA-binding proteins MeCP2-dependent repression of an imprinted miR-184 released by depolarization Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations Unexpected cellular players in Rett syndrome pathology Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients Temporal and epigenetic regulation of neurodevelopmental plasticity.Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets.High levels of MeCP2 depress MHC class I expression in neuronal cells.

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P2860

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

http://www.wikidata.org/entity/Q34387585

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Transcriptional profiling of a ...... iptional changes in the brain.

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Matthew Tudor

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Richard Z Chen

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Schahram Akbarian

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P2860

Identification and characterization of a family of mammalian methyl-CpG binding proteins

A Gene Map of the Human Genome

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Active repression of methylated genes by the chromosomal protein MBD1

Cluster analysis and display of genome-wide expression patterns

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

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