Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.
about
Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro dataBiliary excretion of imatinib and its active metabolite CGP74588 during severe hepatic dysfunction.Pharmacokinetics interaction between imatinib and genistein in rats.Direct inhibition of Re Du Ning Injection and its active compounds on human liver cytochrome P450 enzymes by a cocktail method.CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients.Simultaneous quantification of imatinib and its main metabolite N-demethyl-imatinib in human plasma by liquid chromatography-tandem mass spectrometry and its application to therapeutic drug monitoring in patients with gastrointestinal stromal tumor.A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrelGenetic determinants of anticancer drug activity: towards a global approach to personalized cancer medicine.PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8.Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95.Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib.Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates.Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on pyrimidines, pyridines and pyrroles.Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.Are drug labels static or dynamic?Pharmacology and pharmacokinetics of imatinib in pediatric patients.Toward reduction in animal sacrifice for drugs: molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.CYP2J2 - regulation, function and polymorphism.Inhibitory effect of silybin on pharmacokinetics of imatinib in vivo and in vitro.Treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia with imatinib combined with a paediatric-based protocol.
P2860
Q28533793-70F98A08-5B8E-4A59-994E-1834F6CFDE6BQ33908105-4C1B4D81-FEBC-4F0C-816B-8F6D19E9C7A9Q34986811-353BE62B-A695-4A06-99C6-878BA1833F13Q36205082-65A3E47D-8C61-48D9-9D73-B19DB3F69ACEQ36229161-AD81327B-9B85-4B2B-A886-57C16996426CQ36407123-2325473B-F2A6-4C8D-BEE4-F7343F9FD981Q37316562-1EDF06DC-895D-4B0F-AEC2-92D2C6ACA3F6Q37899883-FCB4CCD3-8513-4AEC-87F9-21D04499C7FAQ38130410-A4491915-1F50-4EAC-9803-BF16C3FDAC18Q38684505-280B18A1-EA15-4D63-9B99-C696795DD954Q39029054-8BD58269-863B-493A-B28A-6C36B12E8847Q40751644-C0B4A9CE-9B2C-4676-BC26-D33468FBE5C5Q42283688-FCAD3547-B201-4E2A-AF5F-BFE39C3F7F1AQ43841175-6E62B46A-5555-4B08-BADD-42BAC86E5DC7Q46431899-1629E7A9-FABB-4718-90B5-6EF36A9BA99FQ47735995-C992B515-B613-4709-8AA9-F06169EED554Q50094239-E36DC332-532E-4784-8005-1E685BF11CA8Q51068004-050230DB-C328-46FF-883E-D79970068DB2Q51709663-B4637A5E-E5F5-45C7-B598-298115A781EFQ53006929-CD07B2F2-78D1-4D23-A464-89D6F5726E03Q54507760-27ED7D3D-50D7-43A9-8E67-C945F3AFB97F
P2860
Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@ast
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@en
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@nl
type
label
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@ast
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@en
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@nl
prefLabel
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@ast
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@en
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@nl
P2093
P2860
P1476
Participation of CYP2C8 and CY ...... b in human hepatic microsomes.
@en
P2093
Bruce Tattam
David E Hibbs
Fabrizio d'Esposito
Michael Murray
Noelia Nebot
Severine Crettol
P2860
P304
P356
10.1111/J.1476-5381.2010.00946.X
P407
P577
2010-11-01T00:00:00Z