Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic - Wikidata - awgldk - TriplyDB

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

http://www.wikidata.org/entity/Q34389172

about

Fhit is a physiological target of the protein kinase Src Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis.Quantifying the mechanisms for segmental duplications in mammalian genomes by statistical analysis and modeling.One in four individuals of African-American ancestry harbors a 5.5kb deletion at chromosome 11q13.1.Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer.Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?Molecular parameters of genome instability: roles of fragile genes at common fragile sites.A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells.Nit1 and Fhit tumor suppressor activities are additive.Very large common fragile site genes and their potential role in cancer development.The Fhit protein: an opportunity to overcome chemoresistance.Impaired replication dynamics at the FRA3B common fragile site.Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma.RORA, a large common fragile site gene, is involved in cellular stress response.The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles.Fhit

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P2860

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

http://www.wikidata.org/entity/Q34389172

description

2003 nî lūn-bûn

@nan

2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

name

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@ast

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@en

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@nl

type

label

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@ast

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@en

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@nl

prefLabel

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@ast

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@en

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@nl

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P356

PNAS.2336256100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Fragile site orthologs FHIT/FR ...... rved but highly recombinogenic

@en

P2093

Ayumi Matsuyama

http://www.w3.org/2001/XMLSchema#string

Francesco Trapasso

http://www.w3.org/2001/XMLSchema#string

Hansjuerg Alder

http://www.w3.org/2001/XMLSchema#string

Kay Huebner

http://www.w3.org/2001/XMLSchema#string

Masaki Mori

http://www.w3.org/2001/XMLSchema#string

Takeshi Shiraishi

http://www.w3.org/2001/XMLSchema#string

Tamotsu Kuroki

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

The tumor spectrum in FHIT-deficient mice

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

Muir-Torre-like syndrome in Fhit-deficient mice

Basic local alignment search tool

Prediction of complete gene structures in human genomic DNA

Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2

P304

14988-14993

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scholarly article

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10.1073/PNAS.2336256100

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P407

P433

25

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P478

100

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Carlo Maria Croce

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2003-11-20T00:00:00Z

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P5875

8996878

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14630947

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P932

299872

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