BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
about
BRCA1 is an essential regulator of heart function and survival following myocardial infarctionInhibition of topoisomerase I prevents chromosome breakage at common fragile sitesComparative genomics and molecular dynamics of DNA repeats in eukaryotesCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesExpanded roles of the Fanconi anemia pathway in preserving genomic stabilityDNA secondary structure at chromosomal fragile sites in human disease.45S rDNA regions are chromosome fragile sites expressed as gaps in vitro on metaphase chromosomes of root-tip meristematic cells in Lolium spp.Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.Secondary structure formation and DNA instability at fragile site FRA16BTranscriptional regulation of the base excision repair pathway by BRCA1Potential biomarkers of DNA replication stress in cancer.DNA instability at chromosomal fragile sites in cancerPremature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Human TopBP1 ensures genome integrity during normal S phasePlant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterationsCycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast.Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.The role of fragile sites in sporadic papillary thyroid carcinomaRegulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa.Replication stress induces tumor-like microdeletions in FHIT/FRA3BIncreased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers.Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16DFANCJ at the FORK.Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders.The biological effects of simple tandem repeats: lessons from the repeat expansion diseases.Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents.The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers.Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.
P2860
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P2860
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/08/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/01)
@nl
наукова стаття, опублікована в серпні 2004
@uk
مقالة علمية (نشرت في أغسطس 2004)
@ar
name
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@ast
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@en
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@nl
type
label
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@ast
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@en
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@nl
prefLabel
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@ast
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@en
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@nl
P2093
P2860
P1476
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
@en
P2093
Anne M. Casper
Martin F. Arlt
Michael B. Kastan
Sandra G. Durkin
Thomas W. Glover
P2860
P304
P356
10.1128/MCB.24.15.6701-6709.2004
P407
P577
2004-08-01T00:00:00Z