MDM2 is a central node in the p53 pathway: 12 years and counting.
about
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENRegulation of p53 stability and function by the deubiquitinating enzyme USP42Expression of the Bcl-3 proto-oncogene suppresses p53 activationMdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53Abrogation of the transactivation activity of p53 by BCCIP down-regulationSmall-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyA positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationFour domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinomaThe role of tumor suppressor p53 in the antioxidant defense and metabolismMice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in ErythropoiesisDiscovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical DevelopmentDiscovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical DevelopmentThe rebel angel: mutant p53 as the driving oncogene in breast cancer.Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsHuman serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified moleculesIdentification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin DSingle nucleotide polymorphisms as susceptibility, prognostic, and therapeutic markers of nonsmall cell lung cancerRapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyMolecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma.Oscillations and variability in the p53 systemMDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner.An information-theoretic analysis of genetics, gender and age in cancer patientsMDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European CaucasiansDiscovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleAssociation between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancerCombined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients.Stress-specific response of the p53-Mdm2 feedback loopInteracting partners of FEN1 and its role in the development of anticancer therapeutics.An integrated analysis of molecular aberrations in NCI-60 cell lines.p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation.MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation.Detection of functional single-nucleotide polymorphisms that affect apoptosisGene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
P2860
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P2860
MDM2 is a central node in the p53 pathway: 12 years and counting.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
MDM2 is a central node in the p53 pathway: 12 years and counting.
@ast
MDM2 is a central node in the p53 pathway: 12 years and counting.
@en
MDM2 is a central node in the p53 pathway: 12 years and counting.
@nl
type
label
MDM2 is a central node in the p53 pathway: 12 years and counting.
@ast
MDM2 is a central node in the p53 pathway: 12 years and counting.
@en
MDM2 is a central node in the p53 pathway: 12 years and counting.
@nl
prefLabel
MDM2 is a central node in the p53 pathway: 12 years and counting.
@ast
MDM2 is a central node in the p53 pathway: 12 years and counting.
@en
MDM2 is a central node in the p53 pathway: 12 years and counting.
@nl
P356
P1476
MDM2 is a central node in the p53 pathway: 12 years and counting.
@en
P2093
Gareth L Bond
P356
10.2174/1568009053332627
P577
2005-02-01T00:00:00Z