RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. - Wikidata - awgldk - TriplyDB

RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.

RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.

http://www.wikidata.org/entity/Q34415722

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes Is the oxidative stress theory of aging dead?Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum.Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family.Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae.Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila Mitochondrial hormesis and diabetic complications Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels Regulation of longevity by regulator of G-protein signaling protein, Loco Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?Mitochondrial manganese superoxide dismutase mRNA expression in human chorioamniotic membranes and its association with labor, inflammation, and infection.Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth Regulation of Drosophila Lifespan by bellwether Promoter Alleles.NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response.Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance.A model of oxidative stress management: moderation of carbohydrate metabolizing enzymes in SOD1-null Drosophila melanogaster.A Sod2 null mutation confers severely reduced adult life span in Drosophila Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.Drosophila melanogaster Prat, a purine de novo synthesis gene, has a pleiotropic maternal-effect phenotype.SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome Life and death: metabolic rate, membrane composition, and life span of animals.Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.Nectarine promotes longevity in Drosophila melanogaster Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging Not all smokers die young: a model for hidden heterogeneity within the human population Pain reduction and improvement in range of motion after daily consumption of an açai (Euterpe oleracea Mart.) pulp-fortified polyphenolic-rich fruit and berry juice blend The oxidizing agent, paraquat, is more toxic to Wolbachia than to mosquito host cells A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals Superoxide dismutase is dispensable for normal animal lifespan A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease Genetic approaches to study aging in Drosophila melanogaster dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.

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P2860

RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.

http://www.wikidata.org/entity/Q34415722

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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type

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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Proceedings of the National Academy of Sciences of the United States of America

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RNA interference-mediated sile ...... d endogenous oxidative stress.

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Arthur J Hilliker

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Jianguo Hu

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John P Phillips

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Kim Kirby

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P2860

Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster

Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements

The genome sequence of Drosophila melanogaster

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly.

A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen.

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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25

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99

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138582

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