Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis.
about
Identification and expression of NEU3, a novel human sialidase associated to the plasma membraneMolecular mechanism of lysosomal sialidase deficiency in galactosialidosis involves its rapid degradationTransport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression.Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assemblyDegradation of G(M1) and G(M2) by mammalian sialidasesNEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signalingHigh-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries.CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia.Human airway epithelia express catalytically active NEU3 sialidaseLysosomal exocytosis and lipid storage disorders.Recent advances in the genetics of epilepsy: insights from human and animal studies.Expression of a novel human sialidase encoded by the NEU2 gene.Mutations in sialidosis impair sialidase binding to the lysosomal multienzyme complex.Splice donor site mutation in the lysosomal neuraminidase gene causing exon skipping and complete loss of enzyme activity in a sialidosis patient.Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient.Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells.LPS-induced cytokine production in human dendritic cells is regulated by sialidase activityPeracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.Molecular background of progressive myoclonus epilepsy.Genetics of inherited human epilepsiesStructural basis for substrate specificity of mammalian neuraminidases.Sialidases as regulators of bioengineered cellular surfaces.NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does notSialic acid metabolism and sialyltransferases: natural functions and applications.Pathogenesis, Emerging therapeutic targets and Treatment in Sialidosis.Neuraminidase-1 is required for the normal assembly of elastic fibersAberrant expression of sialidase and cancer progression.Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis.Influenza neuraminidase: a druggable target for natural products.Sialidase significance for cancer progression.Global Analysis of Protein Expression and Phosphorylation Levels in Nicotine-Treated Pancreatic Stellate Cells.New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability.Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice.Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides.The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites.
P2860
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P2860
Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Cloning, expression and chromo ...... on of mutations in sialidosis.
@ast
Cloning, expression and chromo ...... on of mutations in sialidosis.
@en
Cloning, expression and chromo ...... on of mutations in sialidosis.
@nl
type
label
Cloning, expression and chromo ...... on of mutations in sialidosis.
@ast
Cloning, expression and chromo ...... on of mutations in sialidosis.
@en
Cloning, expression and chromo ...... on of mutations in sialidosis.
@nl
prefLabel
Cloning, expression and chromo ...... on of mutations in sialidosis.
@ast
Cloning, expression and chromo ...... on of mutations in sialidosis.
@en
Cloning, expression and chromo ...... on of mutations in sialidosis.
@nl
P2093
P356
P1433
P1476
Cloning, expression and chromo ...... on of mutations in sialidosis.
@en
P2093
Dallaire L
Elsliger MA
P2888
P304
P356
10.1038/NG0397-316
P407
P577
1997-03-01T00:00:00Z