Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

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http://www.wikidata.org/entity/Q34424619

Q34424619

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COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro Identification of direct protein targets of small molecules Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase Cyclooxygenase-2 in epilepsy.Current perspectives in NSAID-induced gastropathy The Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of Patients With Hepatic Disease: A Review Article Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis How do aspirin and company work? Cyclooxygenases--point of attack of nonsteroidal antirheumatics Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2 Synergistic analgesia of duloxetine and celecoxib in the mouse formalin test: a combination analysis Inhibition mechanism of the intracellular transporter Ca2+-pump from sarco-endoplasmic reticulum by the antitumor agent dimethyl-celecoxib Chemical composition of Nigella sativa Linn: Part 2 Recent advances The effect of celecoxib, a cyclooxygenase-2 inhibitor on noise- induced hearing loss.Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function Efficacy of celecoxib, a cyclooxygenase 2-specific inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug.Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells.Diverse methyl sulfone-containing benzo[b]thiophene library via iodocyclization and palladium-catalyzed coupling.4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2).Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates.Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor.Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors.Anti-inflammatory drugs: a hope for Alzheimer's disease?Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia.Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy.Phospholipase A2 regulates eicosanoid class switching during inflammasome activation Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry.An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition.Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis.Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib.Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.The role of potassium channel activation in celecoxib-induced analgesic action.BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.

P2860

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P2860

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

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http://www.wikidata.org/entity/Q34424619

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1997 nî lūn-bûn

@nan

1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

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1997年论文

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