Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons.
about
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7A single sodium channel mutation produces hyper- or hypoexcitability in different types of neuronsDistinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neuronsA Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivityNeuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel InhibitionGenetic neurological channelopathies: molecular genetics and clinical phenotypes.Primary erythromelalgia: a reviewThe clinical approach to small fibre neuropathy and painful channelopathyNeurobiology: a channel sets the gain on painInfantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese FamiliesContinuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathySubtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.Ototrauma induces sodium channel plasticity in auditory afferent neuronsA gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons.Upregulation of nav1.7 through high salt loading: (mol pain 2013;9:39)Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.Burning pain: axonal dysfunction in erythromelalgia.Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathyAlternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T.Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes.Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disordersSympathetic block for treating primary erythromelalgia.A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia.Challenges in the development of novel treatment strategies for neuropathic pain.Tetrodotoxin (TTX) as a therapeutic agent for pain.Erythromelalgia? A clinical study of people who experience red, hot, painful feet in the communityMexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels.Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons.Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.Ranolazine attenuates behavioral signs of neuropathic pain.Spider peptide toxins as leads for drug development.Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?The roles of sodium channels in nociception: Implications for mechanisms of painHigh-Dose Capsaicin for the Treatment of Neuropathic Pain: What We Know and What We Need to Know.Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancyNav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain.Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.
P2860
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P2860
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@ast
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@en
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@nl
type
label
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@ast
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@en
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@nl
prefLabel
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@ast
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@en
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@nl
P2093
P356
P1433
P1476
Gain-of-function mutation in N ...... s bursting of sensory neurons.
@en
P2093
Cummins TR
Dib-Hajj SD
Marshall L
P304
P356
10.1093/BRAIN/AWH514
P407
P577
2005-06-15T00:00:00Z