Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients. - Wikidata - awgldk - TriplyDB

Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.

Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.

http://www.wikidata.org/entity/Q34428974

about

Molecular pathogenesis and clinical management of Fanconi anemia Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in Childhood Fanconi anemia and the cell cycle: new perspectives on aneuploidy How cell death shapes cancer Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications.Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells Cell cycle control in acute myeloid leukemia.FANCA safeguards interphase and mitosis during hematopoiesis in vivo.Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage DNA interstrand crosslink repair and cancer.SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.Fanconi anaemia: from a monogenic disease to sporadic cancer.Stress and DNA repair biology of the Fanconi anemia pathway The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.Cytokinesis failure and attenuation: new findings in Fanconi anemia.Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice.USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.Stem Cell Therapy for Fanconi Anemia.Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas.Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia.TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice.Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation.A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation.Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia

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Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.

http://www.wikidata.org/entity/Q34428974

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Spontaneous abrogation of the ...... is in Fanconi anemia patients.

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Journal of Clinical Investigation

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Catherine Dubois d'Enghien

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Corinne Pondarre

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Delphine Briot

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Delphine Chamousset

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Hans Joenje

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Jean Soulier

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Jérôme Larghero

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Maria-Elena Noguera

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Nadia Vasquez

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Raphael Ceccaldi

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P2860

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

The DNA-damage response in human biology and disease

Susceptibility pathways in Fanconi's anemia and breast cancer

How the fanconi anemia pathway guards the genome

The combined status of ATM and p53 link tumor development with therapeutic response

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Checkpoints: controls that ensure the order of cell cycle events

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

The DNA damage response: putting checkpoints in perspective

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184-194

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10.1172/JCI43836

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1

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121

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Dominique Stoppa-Lyonnet

Olivier Hermine

Éliane Gluckman

Quinten Waisfisz

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2010-12-22T00:00:00Z

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21183791

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