mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. - Wikidata - awgldk - TriplyDB

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

http://www.wikidata.org/entity/Q34429001

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"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration Tyro3 Modulates Mertk-Associated Retinal Degeneration Protection of retina by αB crystallin in sodium iodate induced retinal degeneration Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression Increased macroautophagy in the pathological process of intervertebral disc degeneration in rats The Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular Degeneration Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium Using current data to define new approach in age related macular degeneration: need to accelerate translational research.Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors.Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice.The retinal pigment epithelium utilizes fatty acids for ketogenesis.Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium Genetics of age-related macular degeneration: application to drug design Autophagy in the eye: implications for ocular cell health.Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy.Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones.Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death.Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial Generation of Cre transgenic mice with postnatal RPE-specific ocular expression T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy.Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration.Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats.How does the macula protect itself from oxidative stress?Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium.Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration Lysosomes: Regulators of autophagy in the retinal pigmented epithelium.Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial.Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.Mitochondrial elongation in the macular RPE of aging monkeys, evidence of metabolic stress.Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability

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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

http://www.wikidata.org/entity/Q34429001

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

@zh-tw

2010年论文

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name

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

@ast

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

@en

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

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type

label

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

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mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

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mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

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prefLabel

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

@ast

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

@en

mTOR-mediated dedifferentiatio ...... receptor degeneration in mice.

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Journal of Clinical Investigation

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mTOR-mediated dedifferentiatio ...... oreceptor degeneration in mice

@en

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Chen Zhao

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Dean Bok

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Douglas Vollrath

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Douglas Yasumura

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Gregory Nielsen

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Joshua L Dunaief

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Kelly Ahern

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Marcia Lloyd

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Matthew M LaVail

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Michael Matthes

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P2860

Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration

A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa

Identification of the gene responsible for Best macular dystrophy

Understanding the Warburg effect: the metabolic requirements of cell proliferation

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

Effects of hypothalamic neurodegeneration on energy balance.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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369-383

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10.1172/JCI44303

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1

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121

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2010-12-06T00:00:00Z

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21135502

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Photoreceptor protein

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3007156

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