Targeting transcription regulation in cancer with a covalent CDK7 inhibitor - Wikidata - awgldk - TriplyDB

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

http://www.wikidata.org/entity/Q34429918

about

Strategically targeting MYC in cancer Targeting cancer with kinase inhibitors Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization Mediator kinase inhibition further activates super-enhancer-associated genes in AML dbSUPER: a database of super-enhancers in mouse and human genome Discovery of host-targeted covalent inhibitors of dengue virus Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers Essential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.A mathematical theory of the transcription repression (TR) therapy of cancer - whether and how it may work.CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor The history and future of targeting cyclin-dependent kinases in cancer therapy.CDK7-dependent transcriptional addiction in triple-negative breast cancer.SEA: a super-enhancer archive.Models of human core transcriptional regulatory circuitries.Targeting cell cycle regulators in hematologic malignancies.Identification and Characterization of an Irreversible Inhibitor of CDK2.Designing Irreversible Inhibitors--Worth the Effort?Covalent targeting of acquired cysteines in cancer THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations.Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript Elongation Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics Strategies to Inhibit Myc and Their Clinical Applicability Targeting Transcription Factors in Cancer DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.

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P2860

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

http://www.wikidata.org/entity/Q34429918

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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Anahita Dastur

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Andrew P Weng

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Arnaud Amzallag

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Bethany Tesar

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Catherine E Jenkins

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Constantine S Mitsiades

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Cyril H Benes

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Douglas McMillin

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Jarrod A Marto

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Jennifer R Brown

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P2860

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

Cdk-activating kinase complex is a component of human transcription factor TFIIH

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes

c-Myc regulates transcriptional pause release

TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Association of Cdk-activating kinase subunits with transcription factor TFIIH

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase

A cyclin associated with the CDK-activating kinase MO15

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616-620

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10.1038/NATURE13393

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Brian J. Abraham

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2014-06-22T00:00:00Z

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