The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

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http://www.wikidata.org/entity/Q34434997

Q34434997

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Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells.Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice.Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Metabolic programming: causes and consequences.FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells.Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence.Role of transcription factor modifications in the pathogenesis of insulin resistance.Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.Association between type 2 diabetes and chronic arsenic exposure in drinking water: a cross sectional study in Bangladesh A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets Estrogens directly potentiate neuronal L-type Ca2+ channels.Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: development of a mouse model for arsenic-induced diabetes Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function.Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.GRFbeta, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain.The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS.Overexpression of the Pdx-1 homeodomain transcription factor impairs glucose metabolism in cultured rat hepatocytes.Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms.Characterization of insulin inhibition of transactivation by a C-terminal fragment of the forkhead transcription factor Foxo1 in rat hepatoma cells.Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220.The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.Glucose enhances insulin promoter activity in MIN6 beta-cells independently of changes in intracellular Ca2+ concentration and insulin secretion Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.Glucose induces glucose 6-phosphatase hydrolytic subunit gene transcription in an insulinoma cell line (INS-1).

P2860

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P2860

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

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http://www.wikidata.org/entity/Q34434997

description

1997 nî lūn-bûn

@nan

1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

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