Identification of a Novel Family of BRAF V600E Inhibitors

Identification of a Novel Family of BRAF V600E Inhibitors

Item
http://www.wikidata.org/entity/Q27678754
Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAFV600E ConformationA graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.The essential roles of chemistry in high-throughput screening triageMitigating risk in academic preclinical drug discovery.Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β2- AR agonizing activities.Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer.Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.Going for broke: targeting the human cancer pseudokinome.Allosteric activation of functionally asymmetric RAF kinase dimers.Kinase regulation by hydrophobic spine assembly in cancer.Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors.Assessing the performance of MM/PBSA and MM/GBSA methods. 5. Improved docking performance using high solute dielectric constant MM/GBSA and MM/PBSA rescoring.Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation
P2860

Identification of a Novel Family of BRAF V600E Inhibitors

Item
http://www.wikidata.org/entity/Q27678754
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of a Novel Family of BRAF V600E Inhibitors
@ast
Identification of a Novel Family of BRAF V600E Inhibitors
@en
Identification of a Novel Family of BRAF V600E Inhibitors
@nl
type
label
Identification of a Novel Family of BRAF V600E Inhibitors
@ast
Identification of a Novel Family of BRAF V600E Inhibitors
@en
Identification of a Novel Family of BRAF V600E Inhibitors
@nl
prefLabel
Identification of a Novel Family of BRAF V600E Inhibitors
@ast
Identification of a Novel Family of BRAF V600E Inhibitors
@en
Identification of a Novel Family of BRAF V600E Inhibitors
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Identification of a Novel Family of BRAF V600E Inhibitors
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932