Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domain.
about
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domainsalpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteinsQuantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal.Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cellsRegulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions.Integrin beta 1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment.Specialized functional properties of the integrin alpha 4 cytoplasmic domain.Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domainsCell adhesion to extracellular matrix regulates the life cycle of integrins.Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly functionIntegrin cytoplasmic domains mediate inside-out signal transduction.Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localizationInduction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding.Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit.beta1-integrin cytoplasmic subdomains involved in dominant negative function.The membrane-cytoplasm interface of integrin alpha subunits is critical for receptor latencyTrans-dominant inhibition of integrin function.Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.Activation-enhanced alpha(IIb)beta(3)-integrin-cytoskeleton interactions outside of focal contacts require the alpha-subunitGraded fibronectin receptor aggregation in migrating cells.Functional characterization of integrin alpha6beta4 adhesion interactions using soluble integrin constructs reveals the involvement of different functional domains in the beta4 subunit.Regulation of integrin function and cellular adhesion.A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis.Role of laminin and integrin interactions in growth cone guidance.Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid.Electric field-directed fibroblast locomotion involves cell surface molecular reorganization and is calcium independent.Modulation of integrin activity is vital for morphogenesisIntracellular signals direct integrin localization to sites of function in embryonic muscles.The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.Nanopatterning of fibronectin and the influence of integrin clustering on endothelial cell spreading and proliferation.Generation of a minimal alpha5beta1 integrin-Fc fragment.Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads.Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.The role of integrins in tumorigenesis and metastasis.Inhibition of Focal Adhesion Kinase Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal.Specific attachment and migration of human astrocytoma cells on human but not murine laminin.
P2860
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P2860
Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domain.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@ast
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@en
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@nl
type
label
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@ast
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@en
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@nl
prefLabel
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@ast
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@en
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@nl
P2093
P2860
P356
P1476
Ligand-dependent and -independ ...... lpha chain cytoplasmic domain.
@en
P2093
E E Marcantonio
R Briesewitz
P2860
P304
P356
10.1091/MBC.4.6.593
P577
1993-06-01T00:00:00Z