Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors. - Wikidata - awgldk - TriplyDB

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors.

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors.

http://www.wikidata.org/entity/Q34440071

about

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition Docking Screens for Novel Ligands Conferring New Biology.Atomic basis of CRM1-cargo recognition, release and inhibition Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Nuclear export mediated regulation of microRNAs: potential target for drug intervention.Nucleo-cytoplasmic transport as a therapeutic target of cancer Structure-based virtual screening for drug discovery: principles, applications and recent advances.KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer Broad targeting of resistance to apoptosis in cancer.Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.General trends of dihedral conformational transitions in a globular protein.Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death.Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition?Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

P2860

Q27307611-B8F56C39-C414-47A1-8F00-B2933942578D Q30489011-1C1DA45F-42A1-4BA0-8F39-64840238451C Q33940712-1F83AC13-D771-4712-B70D-E579A138224B Q33976883-AFF881A3-01EE-4907-92CB-A02180BC977B Q34204130-85CD1F13-845C-4100-8840-FDF30358EC4F Q34452108-F992E9FF-D5BD-4751-8E5E-CB9D5E8C92DB Q35282223-ADAE6035-815C-4612-BC1C-EB5DC2DEC34F Q35856215-634E5F4B-BCA2-4ADA-80C6-271E7BC17058 Q36078792-67ABB645-4E28-493C-8FE1-648295B10FC4 Q36483749-002677B9-4D0E-4C26-AA7E-34AAB66976C2 Q36489494-B0AE4911-C83C-4053-A390-25D189E829FC Q37263168-82770BB8-EFD5-4FD4-8A4E-6DF9D389C4F9 Q37656141-3A727269-7F0E-485C-BC8B-E14C6C5A24EA Q37694722-CC546073-5D19-4E6F-A490-A68419D9248A Q38222341-54B5FF8C-A388-41F9-886F-0051F4766409 Q38390892-268D5A7E-C2BC-4C33-A826-E128DF510140 Q38812797-69A7524E-46C7-420C-A183-5C3FAE0AEB05 Q39677170-F79F1ED3-ADD5-4436-8318-3697C4B4024A Q40963604-6B253B4A-62B9-4924-AD14-8567E8098EA8 Q41360967-97E9BFEE-8764-4FBE-B83F-793540DFCCB1 Q47278858-4D21B90B-0A15-428E-8AA9-70FB95C00131

P2860

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors.

http://www.wikidata.org/entity/Q34440071

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@ast

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@en

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@nl

type

label

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@ast

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@en

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@nl

prefLabel

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@ast

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@en

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@nl

P1433

Q34440071-2C13ABC5-0171-4346-84C4-4D662C914C24

P1476

Q34440071-17AD8AA4-7313-454B-9DE5-ED08459D8D5C

P2093

Q34440071-3FC71B79-28BE-4DFA-8BDE-C4213DB9A039

Q34440071-46FEDCE0-2FA4-4B68-B573-538EB2CF02B1

Q34440071-53B06003-7D32-4DC8-B97C-F0A626470419

Q34440071-67A015CC-8156-49A0-A13E-78F521E1A2E8

Q34440071-B91D2ADA-56E2-40AF-B460-D8F437EC7D74

P2860

Q34440071-0148E7B5-2BDD-4707-AC40-6270BE8011D5

Q34440071-0C54DA65-57B3-4129-B1D4-BD400729B993

Q34440071-16CCCC7C-484C-465B-877C-F12BBF6D9C14

Q34440071-179759DD-2A00-4D7D-BF1A-4D24FA409E6B

Q34440071-1966E80A-BAC0-472D-AB97-F0B677594A18

Q34440071-1B6AACEF-838C-45DE-BEAE-AD7F65E4B1D1

Q34440071-1CA3D4A7-AFAF-4C06-919A-66DDDD3AAC84

Q34440071-1E40A43A-774D-4779-B290-E68933F759BF

Q34440071-234FC71B-694F-4C7E-A7A2-AD4AA508F87F

Q34440071-2CD4D57D-F271-4099-B240-A085DECE578E

P2888

Q34440071-2F025389-A23C-44B1-83D0-3BDA413B4FD0

P304

Q34440071-6F6965C1-5AD1-46D5-BEFD-9F053C8263B7

P31

Q34440071-7559F6B8-8AC8-4931-99AA-04045181D566

P356

Q34440071-CA445536-5A59-4D0B-A474-F9F0773A874F

P433

Q34440071-44150E4D-FA00-4EED-A910-F0147FDB519F

P478

Q34440071-A86D44BF-3F51-4FF6-9E79-698C862A625A

P577

Q34440071-20BF2970-22B9-4F06-97F6-183903BB05B2

P5875

Q34440071-69165516-EF59-4264-8888-C456F9E758B6

P698

Q34440071-02A28BB9-3E60-4BE9-8578-04F2A62C4C1C

P356

S10822-012-9611-9

P1433

Journal of Computer - Aided Molecular Design

P1476

Consensus Induced Fit Docking ...... very of novel Crm1 inhibitors.

@en

P2093

Dora Toledo Warshaviak

http://www.w3.org/2001/XMLSchema#string

Ori Kalid

http://www.w3.org/2001/XMLSchema#string

Sharon Shacham

http://www.w3.org/2001/XMLSchema#string

Sharon Shechter

http://www.w3.org/2001/XMLSchema#string

Woody Sherman

http://www.w3.org/2001/XMLSchema#string

P2860

Rational approaches to improving selectivity in drug design

Structural insights into the stereochemistry of the cyclooxygenase reaction

Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha

Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

P2888

s10822-012-9611-9

P304

1217-1228

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1007/S10822-012-9611-9

http://www.w3.org/2001/XMLSchema#string

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

26

http://www.w3.org/2001/XMLSchema#string

P577

2012-09-30T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

232230395

http://www.w3.org/2001/XMLSchema#string

P698

23053738

http://www.w3.org/2001/XMLSchema#string