KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.
about
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.Leukemic stem cells: identification and clinical application.Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia.A Phase II Trial of Selinexor, an Oral Selective Inhibitor of Nuclear Export Compound, in Abiraterone- and/or Enzalutamide-Refractory Metastatic Castration-Resistant Prostate Cancer.KPT-330 inhibition of chromosome region maintenance 1 is cytotoxic and sensitizes chronic myeloid leukemia to Imatinib.CRM1/XPO1 expression in pancreatic adenocarcinoma correlates with survivin expression and the proliferative activity.Nuclear transport inhibition in acute myeloid leukemia: recent advances and future perspectives
P2860
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P2860
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
KPT-8602, a second-generation ...... and leukemia-initiating cells.
@en
type
label
KPT-8602, a second-generation ...... and leukemia-initiating cells.
@en
prefLabel
KPT-8602, a second-generation ...... and leukemia-initiating cells.
@en
P2093
P2860
P356
P1433
P1476
KPT-8602, a second-generation ...... and leukemia-initiating cells.
@en
P2093
A Berezovskaya
A S Conway
I A Galinsky
M Kauffman
W Senapedis
P2860
P2888
P304
P356
10.1038/LEU.2016.145
P50
P577
2016-05-23T00:00:00Z
P6179
1003119801