Tracking cancer drugs in living cells by thermal profiling of the proteome.
about
Studying epigenetic complexes and their inhibitors with the proteomics toolboxMapping paths: new approaches to dissect eukaryotic signaling circuitryNext-generation sequencing: hype and hope for development of personalized radiation therapy?CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Chemical proteomics approaches for identifying the cellular targets of natural productsThe diverse and expanding role of mass spectrometry in structural and molecular biologycAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometryBinding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAblTime, space, and disorder in the expanding proteome universe.A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets.Tau interactome mappingĀ based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Ferrochelatase is a therapeutic target for ocular neovascularization.Target engagement and drug residence time can be observed in living cells with BRET.Validation and development of MTH1 inhibitors for treatment of cancer.Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs.A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.Global analysis of protein folding thermodynamics for disease state characterizationThermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.Non-stoichiometric inhibition in integrated lead finding - a literature review.Advances in measuring single-cell pharmacology in vivo.Real-Time Biological Annotation of Synthetic Compounds.Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.Ligand and Target Discovery by Fragment-Based Screening in Human Cells.Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Label-free target identification using in-gel fluorescence difference via thermal stability shift.Identification of drug candidates and repurposing opportunities through compound-target interaction networks.Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.The contribution of mass spectrometry-based proteomics to understanding epigenetics.Inhibitors of protein methyltransferases as chemical tools.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.A Biologist's Field Guide to Multiplexed Quantitative Proteomics.Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis.Advances in identification and validation of protein targets of natural products without chemical modification.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.In silico polypharmacology of natural products.
P2860
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P2860
Tracking cancer drugs in living cells by thermal profiling of the proteome.
description
2014 nĆ® lÅ«n-bĆ»n
@nan
2014 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕøÕÆÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
2014 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ°ÕøÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2014幓ć®č«ę
@ja
2014幓č«ę
@yue
2014幓č«ę
@zh-hant
2014幓č«ę
@zh-hk
2014幓č«ę
@zh-mo
2014幓č«ę
@zh-tw
2014幓č®ŗę
@wuu
name
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@ast
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@en
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@nl
type
label
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@ast
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@en
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@nl
prefLabel
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@ast
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@en
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@nl
P2093
P2860
P50
P356
P1433
P1476
Tracking cancer drugs in living cells by thermal profiling of the proteome.
@en
P2093
Daniel Martinez Molina
Dirk Eberhard
Friedrich B M Reinhard
Holger Franken
Marcus Bantscheff
Maria FƤlth Savitski
Mikhail M Savitski
PƤr Nordlund
Rebecca Bakszt Dovega
Thilo Werner
P2860
P304
P356
10.1126/SCIENCE.1255784
P407
P577
2014-10-02T00:00:00Z