Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.
about
Studying epigenetic complexes and their inhibitors with the proteomics toolboxCETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.Identification of protein binding partners of small molecules using label-free methods.The contribution of mass spectrometry-based proteomics to understanding epigenetics.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.Monitoring Cell-surface N-Glycoproteome Dynamics by Quantitative Proteomics Reveals Mechanistic Insights into Macrophage Differentiation.Advances in identification and validation of protein targets of natural products without chemical modification.In silico polypharmacology of natural products.Early Perspective.Detergents: Friends not foes for high-performance membrane proteomics toward precision medicine.A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information.Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics.Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat.Systematic analysis of protein turnover in primary cells.A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells.Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.Pervasive Protein Thermal Stability Variation during the Cell Cycle.Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib.Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift AssayStructural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.A MIXED-EFFECTS MODEL FOR INCOMPLETE DATA FROM LABELING-BASED QUANTITATIVE PROTEOMICS EXPERIMENTS.Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureThermal proteome profiling in bacteria: probing protein state
P2860
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P2860
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Thermal proteome profiling for ...... uantitative mass spectrometry.
@ast
Thermal proteome profiling for ...... uantitative mass spectrometry.
@en
type
label
Thermal proteome profiling for ...... uantitative mass spectrometry.
@ast
Thermal proteome profiling for ...... uantitative mass spectrometry.
@en
prefLabel
Thermal proteome profiling for ...... uantitative mass spectrometry.
@ast
Thermal proteome profiling for ...... uantitative mass spectrometry.
@en
P2093
P2860
P50
P356
P1433
P1476
Thermal proteome profiling for ...... quantitative mass spectrometry
@en
P2093
Carola Doce
Dorothee Childs
Friedrich B M Reinhard
Gavain M A Sweetman
Holger Franken
Mikhail M Savitski
Stephan Gade
Thilo Werner
P2860
P2888
P304
P356
10.1038/NPROT.2015.101
P577
2015-09-17T00:00:00Z