about
Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of DynamicsDynamics-Driven Allostery in Protein KinasesSignaling, Regulation, and Specificity of the Type II p21-activated KinasesDecoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein KinasescAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometryNMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γNon-degradative Ubiquitination of Protein Kinases.Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinomeMapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation FactorsDissecting protein architecture with communication blocks and communicating segment pairs.Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.The allosteric switching mechanism in bacteriophage MS2.Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase AAdvanced molecular dynamics simulation methods for kinase drug discovery.From Type I to Type II: Design, Synthesis, and Characterization of Potent Pyrazin-2-ones as DFG-Out Inhibitors of PDGFRβ.Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.Integration of signaling in the kinome: Architecture and regulation of the αC Helix.A dynamic hydrophobic core orchestrates allostery in protein kinases.Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Development of the first model of a phosphorylated, ATP/Mg2+-containing B-Raf monomer by molecular dynamics simulations: a tool for structure-based design.Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of Ephrin tyrosine kinase evolution.Binding mechanism and dynamic conformational change of C subunit of PKA with different pathways.Protein kinase C: perfectly balanced.Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB.Motor-like Properties of Nonmotor Enzymes.A Computational Approach for Prioritizing Selection of Therapies Targeting Drug Resistant Variation in Anaplastic Lymphoma Kinase.The multifaceted allosteric regulation of Aurora kinase A.Protein dynamic communities from elastic network models align closely to the communities defined by molecular dynamics.Hierarchical Organization Endows the Kinase Domain with Regulatory PlasticityInsights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
P2860
Q26785992-5BF13EE0-3B7E-44D1-9B80-CEA6E5D0A20AQ28081279-68F892F1-DE07-4AAF-9310-9F800219BBE7Q28083745-1C964017-AE47-48AF-A6BD-CB43EBB01783Q28554596-DEA44947-0A21-47F5-9772-6F78DCD628F9Q28822154-8D8AB8DC-92C8-4184-9927-8B79CB9D696CQ28828493-B32D0B6F-6326-4776-98ED-8E82276D7D77Q30388842-0D9EE798-D5B5-4374-B052-EB0ED5EC42D6Q30403000-D4C721E5-9059-4C8B-9C14-4D1C503001F4Q30833549-4746DA6A-F019-4E9B-A981-72298FEEFC40Q33640181-31FB2832-D426-443B-A641-A01DE27EEDE5Q33811883-8440547E-4AFE-4B84-B830-C070654D27D1Q35838268-7B4464F8-1D8C-4FA7-9846-F6B15B437EC5Q35907927-19028D24-A895-4514-9E49-BF8F8222CE9DQ35968819-BBF26192-9913-48E9-9905-0903BB8E4774Q36841051-7C31EA6F-B876-4C85-80F3-47BCBFDF63ABQ37099160-A65DEC64-2AB9-4BE0-98A8-E9D75E009156Q38729941-7650F5F3-EF9A-4B15-B4DF-8094A4413FAEQ38800768-FBD363D2-8379-4D1E-9F09-871F511D8F3BQ39154885-4430BA62-BDBD-43D4-8D7A-A063821EFC82Q40435051-35643BE8-6F60-48EB-A55F-16417B200EB3Q42152183-6C94F004-1A45-40B8-ACAD-C30B604225F2Q42292504-BE4BCB9C-C040-4333-BC48-8D0E45CC3480Q42321745-43F8D626-CA31-4036-BD4C-F7124DE7653FQ43632795-9DFA50C0-5926-484A-B7A5-2ED8DD8F4FCDQ45335193-2F077258-A620-451F-B777-F303913A52E8Q47400707-8C1AB972-9C8D-4599-A0F2-52970364BDACQ47654991-FF359DA9-542A-4687-8481-5EAB707A6454Q50047445-50DDB575-0864-430A-8083-DB88D3889F0EQ50266821-52ACFFD2-17BB-48DF-A880-7E5484FC2CF4Q52669759-463261B5-6F10-402A-9CEA-A83A74177604Q53704466-B0D992BE-0BEB-4D4C-B669-7AF89BB711BDQ54111304-1F32116D-F75F-4258-A9F7-A6D647AF43F9Q54976582-E1BD7D07-63A3-4CEC-8296-4ADFF4B2093CQ55486788-81D0A188-91F4-4897-B2A1-C22D2F02AA06Q55490908-95AD1CEA-0AE4-4231-B931-34423593BA2EQ57790630-8A4A2F4A-F81B-44EE-AD90-EFABC7CCE6AAQ57811390-74B71824-552B-4776-AC7E-F248C60ED509
P2860
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Dynamic architecture of a protein kinase.
@ast
Dynamic architecture of a protein kinase.
@en
Dynamic architecture of a protein kinase.
@nl
type
label
Dynamic architecture of a protein kinase.
@ast
Dynamic architecture of a protein kinase.
@en
Dynamic architecture of a protein kinase.
@nl
prefLabel
Dynamic architecture of a protein kinase.
@ast
Dynamic architecture of a protein kinase.
@en
Dynamic architecture of a protein kinase.
@nl
P2093
P2860
P356
P1476
Dynamic architecture of a protein kinase
@en
P2093
Christopher L McClendon
Michael K Gilson
Susan S Taylor
P2860
P304
P356
10.1073/PNAS.1418402111
P407
P577
2014-10-15T00:00:00Z