Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility.
about
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenitaFinding the end: recruitment of telomerase to telomeresProcessive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditionsA human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongationTelomeres in aging and disease: lessons from zebrafishIt all comes together at the ends: telomerase structure, function, and biogenesisStructurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNAATM Kinase Is Required for Telomere Elongation in Mouse and Human CellsRegulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domainSwitching human telomerase on and off with hPOT1 protein in vitroComparative functional study of the viral telomerase RNA based on natural mutationsFunctional interaction between telomere protein TPP1 and telomeraseTelomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cellsThermodynamic characterization of the Saccharomyces cerevisiae telomerase RNA pseudoknot domain in vitroTriple-helix structure in telomerase RNA contributes to catalysisHuman telomerase RNA template sequence is a determinant of telomere repeat extension rate.Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy.Template boundary definition in mammalian telomeraseA novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.Functional analysis of the pseudoknot structure in human telomerase RNA.Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations.A physical and functional constituent of telomerase anchor site.Ribonucleoprotein multimers and their functions.A Cajal body-independent pathway for telomerase trafficking in mice.Architecture of human telomerase RNA.Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.Analysis of a long-range interaction between conserved domains of human telomerase RNA.The structure of an enzyme-activating fragment of human telomerase RNA.Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies.Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.A novel pseudoknot element is essential for the action of a yeast telomerase.Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of actionThe catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts.Physical Connectivity Mapping by Circular Permutation of Human Telomerase RNA Reveals New Regions Critical for Activity and ProcessivityThe common ancestral core of vertebrate and fungal telomerase RNAs.A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma bruceiA conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity
P2860
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P2860
Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Determinants in mammalian telo ...... cross-species incompatibility.
@ast
Determinants in mammalian telo ...... cross-species incompatibility.
@en
Determinants in mammalian telo ...... cross-species incompatibility.
@nl
type
label
Determinants in mammalian telo ...... cross-species incompatibility.
@ast
Determinants in mammalian telo ...... cross-species incompatibility.
@en
Determinants in mammalian telo ...... cross-species incompatibility.
@nl
prefLabel
Determinants in mammalian telo ...... cross-species incompatibility.
@ast
Determinants in mammalian telo ...... cross-species incompatibility.
@en
Determinants in mammalian telo ...... cross-species incompatibility.
@nl
P2860
P356
P1433
P1476
Determinants in mammalian telo ...... cross-species incompatibility.
@en
P2860
P304
P356
10.1093/EMBOJ/CDG024
P407
P577
2003-01-01T00:00:00Z