The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.
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Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel OpenerNew molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channelsDiverse mechanisms of antiepileptic drugs in the development pipelineMolecular targets for antiepileptic drug developmentACS chemical neuroscience molecule spotlight on Potiga (Ezogabine)Modulating Behavior in C. elegans Using Electroshock and Antiepileptic DrugsThe promise of new antiepileptic drugs.An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development.An assessment of levetiracetam as an anti-epileptic drug.Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats.New anti-epileptic drugs.An assessment of zonisamide as an anti-epileptic drug.Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizuresNeuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.Clinical utility of adjunctive retigabine in partial onset seizures in adults.Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers.One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.Retigabine.Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius.Somatostatin: an endogenous antiepilepticAnimal models for the development of new neuropharmacological therapeutics in the status epilepticus.Profile of retigabine-induced neuronal apoptosis in the developing rat brain.Novel medications for epilepsy.The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.Development of individualized medicine for epilepsy based on genetic information.Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels.The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants.Efficacy of Retigabine on Acute Limbic Seizures in Adult Rats.The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currentsAnticonvulsant Effect of Antiaris toxicaria (Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents.
P2860
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P2860
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@ast
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@en
The new anticonvulsant retigabine
@nl
type
label
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@ast
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@en
The new anticonvulsant retigabine
@nl
prefLabel
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@ast
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@en
The new anticonvulsant retigabine
@nl
P1476
The new anticonvulsant retigab ...... K+ channels in neuronal cells.
@en
P2093
C Rundfeldt
P304
P356
10.1016/S0014-2999(97)01249-1
P407
P577
1997-10-01T00:00:00Z