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Diverse mechanisms of antiepileptic drugs in the development pipeline

Diverse mechanisms of antiepileptic drugs in the development pipeline

http://www.wikidata.org/entity/Q24675330

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Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity Modifications of antiepileptic drugs for improved tolerability and efficacy New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels Molecular targets for antiepileptic drug development Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet Anticonvulsant Effects of Fractions Isolated from Dinoponera quadriceps (Kempt) Ant Venom (Formicidae: Ponerinae)The safety and tolerability of newer antiepileptic drugs in children and adolescents.Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)Probable levetiracetam-related serum alkaline phosphatase elevation.KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment.17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.Acute mania associated with levetiracetam treatment.Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity Lithium acts as a potentiator of AMPAR currents in hippocampal CA1 cells by selectively increasing channel open probability.Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.Beneficial and adverse psychotropic effects of antiepileptic drugs in patients with epilepsy: a summary of prevalence, underlying mechanisms and data limitations.Sodium valproate induced gingival enlargement in 22 months old child.Ion channel pharmacology.Emerging drugs for epilepsy.Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.New Horizons in the development of antiepileptic drugs: Innovative strategies.Novel glutamatergic agents for major depressive disorder and bipolar disorder.A comparative bioavailability study of two formulations of pregabalin in healthy Chilean volunteers.Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets.Currently available antiepileptic drugs.Valproic Acid: second generation.Challenges in the design and conduct of therapeutic trials in channel disorders.Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons Antisense reduction of tau in adult mice protects against seizures Ionotropic glutamate receptors & CNS disorders.Computer modelling of epilepsy Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy.Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ-333369) on rat piriform cortical neurones in vitro.Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Epilepsy Research

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Diverse mechanisms of antiepileptic drugs in the development pipeline

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Impairment of carbamazepine-10, 11-epoxide elimination by valnoctamide, a valpromide isomer, in healthy subjects.

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain

Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells

Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself

The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine

Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action

Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit

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