β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. - Wikidata - awgldk - TriplyDB

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.

http://www.wikidata.org/entity/Q34448671

about

Protein Folding and Mechanisms of Proteostasis Mechanisms of islet amyloidosis toxicity in type 2 diabetes Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells.Protective role of human insulin against the cytotoxicity associated with human mutant S20G islet amyloid polypeptide.Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.Differential proinflammatory and oxidative stress response and vulnerability to metabolic syndrome in habitual high-fat young male consumers putatively predisposed by their genetic background Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human islets Activation of Melatonin Signaling Promotes β-Cell Survival and Function Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.Effects of discontinuing a high-fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats.Type 2 diabetes as a protein misfolding disease.β-Cell failure in type 2 diabetes: a case of asking too much of too few?Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver Islet β cell mass in diabetes and how it relates to function, birth, and death.CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice.β Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.The role of the unfolded protein response in diabetes mellitus.Impaired proteostasis: role in the pathogenesis of diabetes mellitus.SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes.UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?Redox regulation of proteasome function.The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy.An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis.

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P2860

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.

http://www.wikidata.org/entity/Q34448671

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@ast

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@en

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@nl

type

label

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

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β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@en

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@nl

prefLabel

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@ast

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@en

β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

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β-cell dysfunctional ERAD/ubiq ...... ide-induced UCH-L1 deficiency.

@en

P2093

Aleksey V Matveyenko

http://www.w3.org/2001/XMLSchema#string

Alexandra E Butler

http://www.w3.org/2001/XMLSchema#string

Chang-jiang Huang

http://www.w3.org/2001/XMLSchema#string

Marie Daval

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Peter C Butler

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Robert A Rizza

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Safia Costes

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Tatyana Gurlo

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P2860

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

Structure and functions of the 20S and 26S proteasomes

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

The ubiquitin system

ERAD: the long road to destruction

The roles of intracellular protein-degradation pathways in neurodegeneration

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

A role for ubiquitin in selective autophagy

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world

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227-238

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10.2337/DB10-0522

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1

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60

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2010-10-27T00:00:00Z

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47566454

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20980462

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type-2 diabetes

ubiquitin-proteasome system

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3012175

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