A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
about
Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsCuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and CytotoxicityReducing synuclein accumulation improves neuronal survival after spinal cord injuryMolecular Tweezers Targeting Transthyretin AmyloidosisNeurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish EmbryosAmyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicityMolecular basis for preventing α-synuclein aggregation by a molecular tweezer.Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregatesCross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.Binding cavities and druggability of intrinsically disordered proteins.Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.Targeting intrinsically disordered proteins in rational drug discovery.A molecular tweezer antagonizes seminal amyloids and HIV infection.Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules.Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerationsAldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.Intrinsically disordered proteins and novel strategies for drug discovery.α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease.A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.Supramolecular Chemistry Targeting Proteins.Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregationAlpha-synuclein oligomers: a new hope.Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.
P2860
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P2860
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@ast
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@en
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@nl
type
label
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@ast
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@en
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@nl
prefLabel
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@ast
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@en
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
@nl
P2093
P2860
P1433
P1476
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo
@en
P2093
Aida Attar
Arthur G Fitzmaurice
Aswani Kotagiri
Frank-Gerrit Klärner
Jeff M Bronstein
Joseph A Loo
Magdalena I Ivanova
Rajeswari Lakshmanan
Shubhangi Prabhudesai
P2860
P2888
P304
P356
10.1007/S13311-012-0105-1
P577
2012-04-01T00:00:00Z