Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways - Wikidata - awgldk - TriplyDB

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

http://www.wikidata.org/entity/Q34452042

about

A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model High prevalence of hyposalivation in individuals with neurofibromatosis 1: a case-control study.Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.Roles of LIM kinases in central nervous system function and dysfunction.MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells.Targeting LIM kinase in cancer and neurofibromatosis.

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P2860

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

http://www.wikidata.org/entity/Q34452042

description

2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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type

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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prefLabel

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways

@en

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Aurélie Gombault

http://www.w3.org/2001/XMLSchema#string

Aurélie Tchalikian

http://www.w3.org/2001/XMLSchema#string

Béatrice Vallée

http://www.w3.org/2001/XMLSchema#string

Fabienne Godin

http://www.w3.org/2001/XMLSchema#string

Hélène Bénédetti

http://www.w3.org/2001/XMLSchema#string

Marie-Ludivine de Tauzia

http://www.w3.org/2001/XMLSchema#string

Michel Doudeau

http://www.w3.org/2001/XMLSchema#string

P2860

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

Cellular motility driven by assembly and disassembly of actin filaments

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae

The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.

NF1 tumor suppressor gene function: narrowing the GAP

Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules

LIM kinases: function, regulation and association with human disease

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10.1371/JOURNAL.PONE.0047283

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