3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
about
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinaseDifferential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblastsInsulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsVisualization of biochemical networks in living cellsThe mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activityLoss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivationSuppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinDJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathThe phosphatase PHLPP controls the cellular levels of protein kinase CMutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateActivation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaRole of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2The PI3K-PDK1 connection: more than just a road to PKBSerum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayTwo distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityProtein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisA novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulinIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKAA PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansThe proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Self-renewal of embryonic stem cells by a small moleculePhosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseCytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritisThe Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and MetabolismmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceCrystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motifCrystal structures of the S6K1 kinase domain in complexes with inhibitorsPkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity.Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastomaA genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylationImmunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
P2860
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P2860
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@ast
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@en
3-Phosphoinositide-dependent protein kinase 1
@nl
type
label
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@ast
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@en
3-Phosphoinositide-dependent protein kinase 1
@nl
prefLabel
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@ast
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@en
3-Phosphoinositide-dependent protein kinase 1
@nl
P2093
P1433
P1476
3-Phosphoinositide-dependent p ...... 6 kinase in vivo and in vitro.
@en
P2093
P356
10.1016/S0960-9822(98)70037-5
P407
P577
1998-01-01T00:00:00Z