Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. - Wikidata - awgldk - TriplyDB

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

http://www.wikidata.org/entity/Q34460661

about

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling A core function for p120-catenin in cadherin turnover A novel role for p120 catenin in E-cadherin function Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins Emergent complexity of the cytoskeleton: from single filaments to tissue PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility.Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors.A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling.From Alzheimer's disease to skin tumors: the catenin connection.The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.δ-Catenin dysregulation in cancer: interactions with E-cadherin and beyond.Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.Turn-off, drop-out: functional state switching of cadherins.The cadherin family of cell adhesion molecules: multiple roles in synaptic plasticity.Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis.Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration.Emerging roles for p120-catenin in cell adhesion and cancer.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Unconventional Cadherin Localization in Honey Bee Gonads Revealed Through Domain-Specific Apis mellifera E- and N-Cadherin Antibodies Indicates Alternative Functions.P120-Catenin Regulates Early Trafficking Stages of the N-Cadherin Precursor Complex.Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component.P-cadherin expression in breast cancer: a review.Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.Catenins: keeping cells from getting their signals crossed.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.p120-catenin is a key component of the cadherin-gamma-secretase supercomplex.The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer.Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: implications on human prostate cancer progression.

P2860

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P2860

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

http://www.wikidata.org/entity/Q34460661

description

2001 nî lūn-bûn

@nan

2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@ast

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@en

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@nl

type

label

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@ast

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@en

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@nl

prefLabel

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@ast

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@en

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@nl

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Presenilin-1 binds cytoplasmic ...... erin/catenin adhesion complex.

@en

P2093

A Georgakopoulos

http://www.w3.org/2001/XMLSchema#string

E Koo

http://www.w3.org/2001/XMLSchema#string

J Shioi

http://www.w3.org/2001/XMLSchema#string

L Baki

http://www.w3.org/2001/XMLSchema#string

M Ozawa

http://www.w3.org/2001/XMLSchema#string

N K Robakis

http://www.w3.org/2001/XMLSchema#string

P Marambaud

http://www.w3.org/2001/XMLSchema#string

P Wen

http://www.w3.org/2001/XMLSchema#string

S Efthimiopoulos

http://www.w3.org/2001/XMLSchema#string

V L Friedrich

http://www.w3.org/2001/XMLSchema#string

P2860

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Cell binding function of E-cadherin is regulated by the cytoplasmic domain

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species

Regulation of cadherin adhesive activity

Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

P304

2381-2386

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scholarly article

P356

10.1073/PNAS.041603398

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P407

P433

5

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P478

98

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P577

2001-02-01T00:00:00Z

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12105727

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11226248

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30147

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