Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. - Wikidata - awgldk - TriplyDB

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

http://www.wikidata.org/entity/Q34464009

about

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes Potential approaches to the treatment of Ewing's sarcoma Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Dissecting the role of aberrant DNA methylation in human leukaemia.Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish.Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma.DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.Next steps in Ewing sarcoma (epi-)genomics.Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.G-quadruplex structures mark human regulatory chromatin.IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma.Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: progresses and future directions.Transcriptional Addiction in Cancer.EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway.Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.STAT5BN642H is a driver mutation for T cell neoplasia.Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma.Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling.LOLAweb: a containerized web server for interactive genomic locus overlap enrichment analysis.Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species.Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth

P2860

Q26768602-9B242C9E-0001-4F13-8469-78EF8D42FC78 Q26775306-9B4C176C-4FEE-4789-98AC-953836898FA0 Q26782842-A791E937-AFC2-4D4E-81AD-4DE8DD60B5AA Q26801785-EB7A2EE5-C3D8-496F-B035-4FFFCDDFB13B Q28072744-4D076A02-C937-4C9D-9428-F3B2133654F6 Q33798299-E9AF3341-88D6-4598-919B-6D3B1D0CEEBA Q34492346-D8098CB3-FB4B-40FB-870E-6E8457DAEFF1 Q35645500-54459B36-6376-40CA-8C0F-CAA135EAF3AD Q36738866-9BE76CB2-86E9-4D25-A6D2-D92DF35DA1B7 Q37203270-F6082ACB-358C-40BB-BA9D-ADA17E6B78A4 Q37222057-3E482FC8-EFCF-4A92-97BF-79DD47779BFC Q37269236-66D0A5D9-BEAA-4021-87ED-7AE44B0B4DB5 Q37702254-8DF9DFD6-CDA2-47C1-900E-6CCF88893498 Q38270137-8075BF97-8075-4962-80DD-9152513CF82E Q38289575-C9C3D25D-2CEC-4B04-A073-E3E54AC1AEC7 Q38373823-85BC6B9E-3DAA-447D-93B2-7790216EA38D Q38673853-A1CB5E33-DE29-44EB-871D-08B3038D8267 Q38694375-D9307BF9-FF74-4DCB-93D0-224314918B56 Q38696838-0B141A2C-4121-48B0-8331-06C333620BED Q38746800-2823A7E3-EB41-4126-A5CC-589F55F47237 Q38748961-73094FB6-64ED-4BEE-ABD3-62F3E38F0A25 Q38760598-BBB7249D-069B-4A80-8030-AD27C7EC17C1 Q38819288-BF457792-779F-4E69-8AD4-D2E12200F15B Q38851252-B12A5AC5-0726-4FC2-A956-AD18BDFD2420 Q39130428-16480F25-2F93-42A9-B6BD-C085BF437A06 Q39634845-68051C87-E987-479C-958D-5E392246373F Q42321604-18775F8A-5D65-4026-9EE3-36C768F1D7CB Q42350421-571EFEA1-C642-4232-AA38-86E1166C229C Q46131586-39074C53-8E71-480B-8C5C-563D66869D71 Q47375997-4062812E-24AC-4E5B-A96D-0C26AB03F483 Q49166444-1984D62C-105A-408C-A4AD-4D0762563DED Q53834599-06AB9B15-AF7D-4E89-8934-2CC8C540571C Q55030833-6D87D087-02D7-4C68-BF05-0C2F8E29C75C Q55491402-00D3B01A-4F37-41FB-87BE-9535C12CA499 Q55515822-505665B8-080C-4DD1-A4FA-B775754A370D Q57174958-84DAD9D8-0E17-4D69-8ABD-6F10B7E01393 Q58764432-66E4D574-DEC3-4957-A74D-9F6C4B316AD7

P2860

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

http://www.wikidata.org/entity/Q34464009

description

2015 nî lūn-bûn

@nan

2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@ast

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@en

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@nl

type

label

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@ast

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@en

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@nl

altLabel

Epigenome mapping reveals dist ...... ogenic fusion protein EWS-FLI1

@en

prefLabel

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@ast

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@en

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@nl

P1433

Q34464009-1F06B93E-F342-46FD-B683-F5F4B18D9C19

P1476

Q34464009-81C60ABF-5929-4F8A-9E83-E712395A0F7F

P2093

Q34464009-582EAA92-9D77-45B2-9D62-BA5C7B745D64

Q34464009-5DBBA20E-1D91-40C5-BA36-9FE0D08B3642

P2860

Q34464009-01952B21-2A68-407E-AC32-DE093B3A28DB

Q34464009-0877A952-F28F-4164-9804-F2EAD940D389

Q34464009-117D40B8-A7F2-446E-8AF0-947EFE1B64B2

Q34464009-13157373-9367-46FA-A2A8-D78C0E34D58E

Q34464009-140AAA6F-84E5-448B-BBF9-E8FCEFC3C023

Q34464009-225E218A-D2F7-43A6-9A12-2FD66EB82706

Q34464009-2716524F-A2F1-42E9-B38C-88477D01DB78

Q34464009-4D6DF31A-5225-4202-A141-9853324C3C91

Q34464009-500CF7E0-6274-4342-9E3E-8DF94B97D22B

Q34464009-50BCE836-C8EA-4EA3-8ED5-796597846B54

P304

Q34464009-293FA76D-B605-4A33-9983-7BCCDBFE7273

P31

Q34464009-0A9CFF58-0EDD-4EC5-AEDF-57A7A6EF904C

P356

Q34464009-9C6D3BF4-B9A9-4D4C-BE2B-01FA81473762

P407

Q34464009-8BFCC12E-9695-4DB3-8696-92EB27E100C7

P433

Q34464009-890363C1-F0F9-4FAD-B768-144D4630896F

P478

Q34464009-BBEC0ADB-0BF2-434E-9657-06471222DF5D

P50

Q34464009-07006845-32D5-44A6-A71E-98ED1DB69C63

Q34464009-0DCB6C72-D7E3-42A9-9E4E-E32ACEDA7DD4

Q34464009-11854567-43D9-40C1-B9F8-54C7708827A9

Q34464009-21E751D4-7C3F-499E-BD57-A19DA0272FC8

Q34464009-294D8629-ECC6-4536-95B7-75216EA307D9

Q34464009-4B10B1E1-E7F2-4CE2-8FD7-8B1A508A9C20

Q34464009-983DF944-EF64-4114-B7C2-105865CBB558

P577

Q34464009-78A41481-85A3-456F-9704-A0066A70C9E7

P698

Q34464009-AEC0277E-E97B-491B-9EC3-3C7D144B62BC

P932

Q34464009-B06C231B-26FF-4B04-BF78-4AA8B0C3F3D5

P356

J.CELREP.2015.01.042

P1433

P1476

Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.

@en

P2093

Christian Schmidl

http://www.w3.org/2001/XMLSchema#string

Eleni M Tomazou

http://www.w3.org/2001/XMLSchema#string

P2860

An integrated encyclopedia of DNA elements in the human genome

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Histone H3K27ac separates active from poised enhancers and predicts developmental state

The genomic landscape of pediatric Ewing sarcoma.

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

Ewing's sarcoma family of tumors: current management

EWS/Fli-1 chimeric protein is a transcriptional activator

Super-enhancers in the control of cell identity and disease

A unique chromatin signature uncovers early developmental enhancers in humans

Selective inhibition of tumor oncogenes by disruption of super-enhancers

P304

1082-1095

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CELREP.2015.01.042

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P50

Michael Schuster

Nathan C. Sheffield

Andreas Schönegger

P577

2015-02-19T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25704812

http://www.w3.org/2001/XMLSchema#string

P932

4542316

http://www.w3.org/2001/XMLSchema#string